Hand Jing-Well Acupoint Stimulation for Post-Stroke Cognitive Impairment

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This randomized study tests transcutaneous electrical stimulation applied to hand Jing-Well acupoints in adults 35-80 with ischemic stroke and mild to moderate cognitive impairment. Participants are assigned to active stimulation or a sham control for four weeks, with sessions six times per week lasting 30 minutes at 10 Hz, adjusted to tolerance. Cognitive tests and brain imaging are used before and after treatment to assess changes. The goal is to determine whether this non-invasive therapy can improve cognitive function in post-stroke patients beyond placebo effects.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Aged 35-80 years;
2. Stroke duration within 2 weeks to 6 months post-onset;
3. Cognitive impairment confirmed by neuropsychological assessment: Montreal Cognitive Assessment (MoCA) score \< 26;
4. Clinical evaluation excludes delirium, major depressive disorder, schizophrenia, or other primary psychiatric/behavioral disorders as the principal cause of current cognitive impairment. No history of other known neurological diseases that may cause cognitive impairment (e.g., multiple sclerosis, encephalitis, Parkinson's disease, post-traumatic dementia, normal pressure hydrocephalus, etc.);
5. No severe aphasia; able to cooperate with scale assessments and complete the treatment protocol required by this study;
6. Voluntary participation in this study; the participant or their legally authorized representative has signed the informed consent form.

Exclusion Criteria:

1. Unstable vital signs or life-threatening comorbidities;
2. Implanted devices (cardiac pacemaker/defibrillator, deep brain stimulator, etc.);
3. History of epilepsy or epileptic seizures;
4. Pregnant or lactating women;
5. Concurrent use of other medications affecting cognitive function;
6. Allergy to the study intervention device or history of serious adverse reactions;
7. Severe arrhythmia, malignant hypertension, or severe dysfunction of vital organs (heart, liver, kidney, etc.);
8. Individuals unable to participate in treatment due to severe hearing or visual impairment, or bilateral limb paralysis.

Where it's running

• The First Teaching Hospital of Tianjin University of Traditional Chinese Medicine
  Tianjin, Tianjin Municipality, China Recruiting

Study contacts

• Study coordinator: Liang Gao
• Email: Gaoliang202605@163.com
• Phone: 8618722216295

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.