Gut leakage in dengue: is the intestinal barrier affected during infection?

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study will examine adults hospitalized with dengue to see if markers of gut barrier dysfunction (gut leakage) are present and how they relate to disease severity. It will compare dengue patients to healthy adults and assess intestinal permeability within 24 hours of hospital admission. The study aims to understand whether gut leakage plays a role in the progression to more severe dengue, including plasma leakage. No interventions are described; observational data will be collected through clinical assessment and laboratory tests. Enrollment is limited to a single site in Chittagong, Bangladesh, with lead sponsorship from the University of Oxford.

Why it matters

Who can join: the full rules

Inclusion Criteria:

Dengue participants

* Participant/ legally authorised representative willing and able to give informed consent for participation in the study.
* Male or Female, adults ≥18 years
* Diagnosed as a case of Dengue on the basis of clinical features and positive NS1 antigen and/or IgM dengue antibody
* Hospitalized in medicine or dengue ward in Chittagong Medical College Hospital.
* Enrolled within 24 hours of hospitalization.

Healthy participants

* Participant/ legally authorised representative willing and able to give informed consent for participation in the study.
* Male or Female, adults ≥18 years
* Clinically healthy with no acute or chronic illness
* Attendant of a dengue patient (not a patient)

Exclusion Criteria:

Dengue participants

* Unable to provide consent or participate in follow-up procedures
* Known chronic gastrointestinal (GI) disease affecting intestinal permeability (IBD, celiac disease), chronic liver disease, active chronic diarrhoea, short bowel loop syndrome, recent (\<3 months) major GI surgery.
* Immunosuppression (for example chemotherapy, high-dose steroids), advanced chronic kidney disease, decompensated heart failure.
* Drugs that can alter the level of biomarkers in blood like metformin, statin, probiotics, steroid within last 48 hours of hospitalization.
* Pregnancy

Healthy participants

* Unable to provide consent
* Known chronic gastrointestinal (GI) disease affecting intestinal permeability (IBD, celiac disease), chronic liver disease, active chronic diarrhoea, short bowel loop syndrome, recent (\<3 months) major GI surgery.
* Immunosuppression (for example chemotherapy, high-dose steroids), advanced chronic kidney disease, decompensated heart failure.
* Drugs that can alter the level of biomarkers in blood like metformin, statin, probiotics, steroid within last 48 hours of hospitalization.
* Pregnancy
* History of current or recent dengue or other arbo viral infection

Where it's running

• Department of Medicine, Chittagong Medical College
  Chittagong, Chattogram Division, Bangladesh Recruiting

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.