Egg intake and gut health, HDL, and immune markers in adults

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional study examines how daily consumption of egg whites versus whole eggs influences gut microbiome composition and metabolome, HDL particles and function, and immune cell behavior in adults aged 18 to 50 across BMI categories. Participants will alternate between eating egg whites and whole eggs for four weeks each, with an eight-week period of egg abstinence in between. Researchers will analyze baseline microbiome data to see if initial gut communities modify egg-related effects and will also explore potential differences between sexes and BMI groups. The trial uses ex vivo immune assays to assess functional immune responses related to egg intake.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* 18-50 years old (at time of screening)
* Premenopausal status for women
* Body mass index (BMI) 18.5 to \< 25 kg/m2; or ³ 30 kg/m2 and \>30% and \>40% body fat for men and women, respectively
* Willing to consume whole eggs and egg whites provided during the study on a daily basis, and refrain from other eggs or egg-based foods and beverages during the study
* Do not fit any exclusion criteria

Exclusion Criteria:

* \<18 years old and ≥ 51 years old
* BMI \<18.5, 25-29.9, or body weight \< 110 pounds
* Experienced \>10% weight change in the past 4 weeks
* Elevated fasting glucose levels (fasting glucose higher than 126 mg/dL) and triglycerides greater than 500 mg/dL, or total cholesterol \< 120 mg/dL and HDL- cholesterol \< 15 mg/dL
* Self-reported and/or physician-diagnosed history of severe constipation, diabetes mellitus, coronary heart disease, stroke, renal or liver disease, cancer, eating disorders, certain severe and/or relapsing/remitting autoimmune, inflammatory, intestinal or metabolic diseases, chronic infections, scleroderma, blood clotting disorders, intravenous drug use, or current pregnancy or lactation, postmenopausal
* Allergy to eggs
* Implanted medical device (e.g., pacemaker) or other health condition that would prevent measurement of body composition by bioelectrical impedence
* Currently taking lipid-lowering medications (e.g., statins, fibrates), glucose-regulating medications, anti-inflammatory medications (e.g., NSAIDs, corticosteroids), or medications that primarily affect blood clotting (e.g., warfarin), long-term antibiotics or probiotics in the last 3 months or during the intervention
* Active smoker

Where it's running

• University of Connecticut
  Storrs, Connecticut, United States Recruiting

Study contacts

• Study coordinator: Catherine J Andersen, PhD, RDN
• Email: catherine.andersen@uconn.edu
• Phone: 860-486-1704

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.