Combining 10-day Fasting with Fibre to Boost Gut Health
Official title: Combining Fasting and Fibre Interventions to Optimise Their Gut Microbiome-mediated Health Benefits
Run by Buchinger Wilhelmi Development & Holding GmbH · NCT07691736 · Data updated 2026-11-12
This study tests whether adding dietary fibre to a 10-day fast improves gut microbiome function and metabolic health in adults with overweight or obesity.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 65 Years |
| Sex | All |
| Enrollment | 75 (estimated) |
| Sponsor | Buchinger Wilhelmi Development & Holding GmbH Academic / other |
| Locations | 1 site (Überlingen, Baden-Wurttemberg) |
| Status | Recruiting |
| Started | August 31, 2026 |
| Main results expected | February 28, 2027 |
| Study ends | March 2027 |
| Registry record updated | September 30, 2026 |
| Trial ID | NCT07691736 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 18–65 with BMI ≥25 kg/m² who are able to undergo a 10±4 day fast at the Buchinger Wilhelmi clinic and meet consent criteria.
✕Probably not a fit
Individuals with certain GI diseases, diabetes, kidney or liver insufficiency, or those on antibiotics or probiotics recently may not benefit or may be excluded.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
Participants undergo a fasting period of about 10 days at the Buchinger Wilhelmi clinic. The trial compares two groups: fasting with fibre supplementation versus fasting without fibre, to see if the fibre enhances gut microbiome outputs and metabolic markers such as butyrate production, glucose control, and ketone levels. The study analyzes gut microbiome changes, functional outputs, and key metabolic outcomes to assess potential synergistic effects. It is a proof-of-concept, randomized controlled design with 75 adults aged 18–65 and BMI ≥25 kg/m². Primary results focus on whether adding fibre to a prolonged fast yields greater metabolic benefits mediated by the gut microbiome.
Why it matters
Potential benefit: If successful, the approach could offer a practical strategy to enhance metabolic health during fasts by leveraging the gut microbiome.
How similar studies have gone: Previous research shows fasting and prebiotic interventions can positively affect the gut microbiome and metabolism, but this exact combination is being tested here.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Men and women * Age: 18-65 years old * Fasting for 10±4 days at the Buchinger Wilhelmi clinic in Überlingen * BMI ≥ 25 kg/m² * Signed informed consent Exclusion Criteria: * intake of antibiotics up to 2 months prior the study * regular intake of pre-, post- and probiotics up to 2 months prior the study * diagnosed Crohn's disease, Ulcerative colitis, IBD, coeliac disease * medicated high blood pressure * diagnosed diabetes mellitus type I * medicated diabetes mellitus type II * diagnosed kidney stone * active malignant disease * known substance addiction * pregnancy or breastfeeding * diagnosed with cachexia, anorexia nervosa, advanced kidney, liver or cerebrovascular insufficiency * inability to sign the informed consent * participation in another study
Where it's running
-
Buchinger Wilhelmi Development & Holding
Überlingen, Baden-Wurttemberg, Germany Recruiting
Study contacts
- Principal investigator: Andrea Siegler, Dr. med. — Buchinger Wilhelmi Development & Holding
- Study coordinator: Elena Katharina Stroppel
- Email: katharina.stroppel@buchinger-wilhelmi.com
- Phone: 00497551807675
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.