GRADY: a computer tool to detect early sepsis and gram-negative bloodstream infection in ICU patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a prospective, single-center validation of the GRADY machine-learning models using routinely collected vital signs and laboratory data from adult ICU patients. The study will enroll patients who remain in the ICU at least 48 hours and have blood cultures taken, and will compare GRADY's predictions to standard scoring systems such as SOFA, SIRS, and NEWS2. Primary outcomes include detection accuracy for gram-negative bacteremia and sepsis versus blood culture-confirmed infection and clinical sepsis definitions. The protocol also explores how GRADY might be integrated as an early warning tool to support more rapid clinical intervention.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients aged 18 years or older
* ICU stay of 48 hours or longer
* Patients from whom blood cultures were obtained during routine monitoring
* Signed informed consent form

Exclusion Criteria:

* Patients younger than 18 years
* ICU stay shorter than 48 hours
* Patients without blood cultures

Where it's running

• Sisli etfal research and training hospital
  Seyrantepe, Istanbul, Turkey (Türkiye) Recruiting

Study contacts

• Study coordinator: okan derin
• Email: okanderin@gmail.com
• Phone: +905053580264

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• UllCORE BSI Test for Bloodstream Infections

  This study tests whether the UllCORE BSI Test can correctly detect bloodstream infection pathogens and resistance markers from whole blood in people with suspected infection or sepsis.

  Recruiting Deepull Diagnostics S.L. · Orange, California and 19 other locations · NCT07859852

• Beta-lactam plus levofloxacin for streptococcal bacteremia

  This trial tests whether adding levofloxacin to standard beta-lactam therapy helps adults with streptococcal bacteremia see better outcomes.

  Recruiting at 2 sites Phase 4 Mahidol University · Bangkok and 3 other locations · NCT07240077

• Blood cultures from arterial lines: does it change contamination, bacteremia detection, and how much blood is drawn?

  This study tests whether drawing blood cultures from arterial lines affects contamination rates, how well bacteremia is detected, and the volume of blood collected in ICU patients.

  Recruiting Meir Medical Center · Kfar Saba · NCT07183410

• New care guideline for infants 60 days and younger with fever in Sweden

  This project will test a new guideline to see if infants 60 days or younger with fever can safely avoid many invasive tests, hospital stays, and broad antibiotics compared with usual care.

  Recruiting at 9 sites Region Skane · Gothenburg and 10 other locations · NCT07134751

• Linezolid added to standard care for Staphylococcus aureus bloodstream infection

  This trial will test whether giving linezolid in addition to usual antibiotics helps adults hospitalized with Staphylococcus aureus bloodstream infections.

  Recruiting at 12 sites University Hospital, Basel, Switzerland · Aarau, Canton of Aargau and 11 other locations · NCT06958835

• Examining biofilm in arterial catheters in ICU patients

  This study looks at the germs that build up on arterial catheters in ICU patients to see how they might cause infections and find better ways to prevent them.

  Recruiting at 2 sites Centre Hospitalier William Morey - Chalon sur Saône · Dijon, Bourgogne-Franche-Comté and 1 other locations · NCT06838598

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.