Genetic analysis of healthy Egyptians to understand heart disease

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to define the genetic makeup of a healthy cohort of Egyptian adults to establish a baseline for identifying genetic mutations associated with inherited cardiomyopathies. Utilizing advanced whole genome sequencing technology, researchers will compare the genomes of healthy volunteers with those of patients diagnosed with cardiomyopathies. The study seeks to systematically analyze genetic variants to determine their clinical significance and implications for heart disease in the Egyptian population. By creating a reference for normal genetic variants, the study will enhance understanding of genetic predispositions to cardiovascular conditions.

Why it matters

Who can join: the full rules

* Inclusion Criteria:

  * Any adult Egyptian citizen subject that considers him/herself free of cardiovascular disease.
* Exclusion Criteria:

  * Individuals under 18 years of age
  * Known cardiovascular disease
  * Known collagen vascular disease
  * Individuals with communication difficulties, or who do not wish to participate
  * Pregnancy
  * Contraindication to MRI
  * Family history of sudden death
  * Family history of a familial cardiomyopathy
  * Family history of premature coronary artery disease (males \<40 years, females \<50 years).
* Withdrawal Criteria:

  * Withdrawal of consent.

Where it's running

• Aswan Heart Centre - Magdi Yacoub Heart Foundation
  Aswān, Egypt Recruiting

Study contacts

• Principal investigator: Magdi H Yacoub, FRS OM — Imperial College London, and Magdi Yacoub Heart Foundation
• Study coordinator: Yasmine Aguib, PhD
• Email: yasmine.aguib@aswanheartcentre.com
• Phone: +201092036368

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.