Genetic analysis of healthy Egyptians to understand heart disease
Aswan Heart Centre - Egyptian Healthy Volunteers
This study is trying to understand the genetic differences in healthy Egyptians to help identify what might lead to heart disease in people with inherited heart conditions.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 1000 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Magdi Yacoub Heart Foundation Academic / other |
| Locations | 1 site (Aswān) |
| Trial ID | NCT05661305 on ClinicalTrials.gov |
What this trial studies
This observational study aims to define the genetic makeup of a healthy cohort of Egyptian adults to establish a baseline for identifying genetic mutations associated with inherited cardiomyopathies. Utilizing advanced whole genome sequencing technology, researchers will compare the genomes of healthy volunteers with those of patients diagnosed with cardiomyopathies. The study seeks to systematically analyze genetic variants to determine their clinical significance and implications for heart disease in the Egyptian population. By creating a reference for normal genetic variants, the study will enhance understanding of genetic predispositions to cardiovascular conditions.
Who should consider this trial
Good fit: Ideal candidates for this study are adult Egyptian citizens who are free of cardiovascular disease.
Not a fit: Patients with known cardiovascular disease or related familial histories may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved genetic screening and personalized treatment strategies for heart disease in the Egyptian population.
How similar studies have performed: Other studies have successfully utilized whole genome sequencing to identify genetic variants in different populations, suggesting potential for success in this novel approach.
Eligibility criteria
Show full inclusion / exclusion criteria
* Inclusion Criteria: * Any adult Egyptian citizen subject that considers him/herself free of cardiovascular disease. * Exclusion Criteria: * Individuals under 18 years of age * Known cardiovascular disease * Known collagen vascular disease * Individuals with communication difficulties, or who do not wish to participate * Pregnancy * Contraindication to MRI * Family history of sudden death * Family history of a familial cardiomyopathy * Family history of premature coronary artery disease (males \<40 years, females \<50 years). * Withdrawal Criteria: * Withdrawal of consent.
Where this trial is running
Aswān
- Aswan Heart Centre - Magdi Yacoub Heart Foundation — Aswān, Egypt (Recruiting)
Study contacts
- Principal investigator: Magdi H Yacoub, FRS OM — Imperial College London, and Magdi Yacoub Heart Foundation
- Study coordinator: Yasmine Aguib, PhD
- Email: yasmine.aguib@aswanheartcentre.com
- Phone: +201092036368
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.