A network for advancing genomics research and improving health

Helix Research Network

This study is testing how sharing genetic information from patients can help doctors better understand diseases and improve treatments for everyone involved.

Quick facts

• Study type: Observational
• Enrollment: 2000000 (estimated)
• Ages: 18 Years and up
• Sex: All
• Sponsor: Helix, Inc (industry)
• Locations: 14 sites (Fort Wayne, Indiana and 13 other locations)
• Trial ID: NCT06057181 on ClinicalTrials.gov

What this trial studies

The Helix Research Network is a collaborative initiative involving various healthcare organizations aimed at enhancing medical research through large-scale genomics. It focuses on creating a comprehensive clinicogenomics dataset to identify genetic and molecular factors influencing disease risk, progression, and treatment responses. Participants will undergo exome sequencing and receive annual reports on their health outcomes and the study's impact. The network aims to integrate genomic data into clinical care to improve diagnosis and treatment for individuals.

Who should consider this trial

Good fit: Ideal candidates for this study are individuals aged 18 and older who are willing to comply with the study protocol.

Not a fit: Patients with a history of allogenic bone marrow or stem cell transplants may not benefit from this study.

Why it matters

Potential benefit: If successful, this initiative could lead to more personalized and effective medical treatments based on genetic information.

How similar studies have performed: Other studies utilizing large-scale genomic data have shown promise in identifying disease risk factors and improving patient outcomes, indicating a favorable outlook for this approach.

Eligibility criteria

Inclusion Criteria:

* 18 years and older
* Willing and able to comply with all aspects of the protocol

Exclusion Criteria:

* History of allogenic bone marrow transplant
* History of allogenic stem cell transplant
* Anything that would place the individual at increased risk or preclude an individual's: 1) full compliance with study requirements; or 2) completion of the study based on the assessment from local consenting and enrolling Investigators.

Where this trial is running

Fort Wayne, Indiana and 13 other locations

• Parkview Health (DNA Insights) — Fort Wayne, Indiana, United States (RECRUITING)
• HealthPartners (myGenetics) — Bloomington, Minnesota, United States (RECRUITING)
• Nebraska Medicine - University of Nebraska Medical Center (Genetic Insights Project) — Omaha, Nebraska, United States (RECRUITING)
• Renown Health (Healthy Nevada Project) — Reno, Nevada, United States (RECRUITING)
• Rochester Regional Health (GenoWell) — Rochester, New York, United States (RECRUITING)
• Cone Health (Gene Connect) — Burlington, North Carolina, United States (RECRUITING)
• WakeMed (PreciselyYou) — Raleigh, North Carolina, United States (RECRUITING)
• TriHealth (DNA Discovery) — Cincinnati, Ohio, United States (RECRUITING)
• The Ohio State University (Genomic Health) — Columbus, Ohio, United States (RECRUITING)
• St. Luke's University Health Network (DNAanswers) — Bethlehem, Pennsylvania, United States (RECRUITING)
• WellSpan Health (The Gene Health Project) — York, Pennsylvania, United States (RECRUITING)
• Medical University of South Carolina (In Our DNA SC) — Charleston, South Carolina, United States (RECRUITING)
• Sanford Health (Imagine You) — Sioux Falls, South Dakota, United States (RECRUITING)
• Memorial Hermann Health System (genoME) — Houston, Texas, United States (RECRUITING)

Study contacts

• Principal investigator: William Lee, PhD — Helix, Inc
• Study coordinator: Layla Anderson

Conditions: Genetic Predisposition to Disease, Genetics Disease