Functional Lung-Sparing Planning Guided by Lung Perfusion PET/CT vs. Anatomy for Lung SBRT

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This phase 3 trial compares two planning approaches for lung SBRT. One uses conventional anatomical planning, and the other uses functional lung avoidance planning based on 68Ga-MAA perfusion PET/CT to spare functioning lung regions. The goal is to reduce radiation-induced lung injury while maintaining tumor control. Eligible participants are adults planned for SBRT to primary or secondary lung tumors at participating centers. Outcomes focus on pulmonary toxicity, lung function, and treatment effectiveness.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients aged \> 18 years planned to be treated in the radiotherapy department of the participating centers with SBRT for primary or secondary lung tumors will be eligible to participate into the study

Exclusion Criteria:

* Inability to give informed consent
* Patientsunder guardianship or curatorship
* Pregnant or breastfeeding women.
* Contraindications to the radiolabeled product infused for lung perfusion PET/CT.

Where it's running

• CHU Brest
  Brest, Finistère, France Recruiting
• Centre de Lutte Contre le Cancer Leon Bérard Lyon
  Lyon, France Not yet recruiting

Study contacts

• Study coordinator: Pierre-Yves Le Roux, Professeur
• Email: Pierre-yves.leroux@chu-brest.fr
• Phone: +33 2 98 22 31 17

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.