From Commensal to Pathogenic Enterococcus: Understanding How Enterococcus faecalis Causes Endocarditis
Official title: From Commensalism to Pathogenicity: Exploring the Pathophysiology of Bacteremia to Better Understand Enterococcus Faecalis Infective Endocarditisléter
Run by University Hospital, Clermont-Ferrand · NCT07313865 · Data updated 2026-11-12
This study tests how Enterococcus faecalis from the gut can lead to infective endocarditis in adults who have a positive blood culture and are on antibiotics, to better understand why it becomes dangerous.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 90 (estimated) |
| Sponsor | University Hospital, Clermont-Ferrand Academic / other |
| Locations | 1 site (Clermont-Ferrand, France) |
| Status | Recruiting |
| Started | April 17, 2026 |
| Main results expected | December 31, 2028 |
| Study ends | December 31, 2028 |
| Registry record updated | October 13, 2026 |
| Trial ID | NCT07313865 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults 18 years or older with a positive Enterococcus faecalis blood culture and on antibiotics, able to consent, and treated at the enrolling hospital.
✕Probably not a fit
Patients whose infection resolves quickly with standard care or whose samples cannot yield actionable data may not directly benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This interventional study collects microbiological samples from adults hospitalized with Enterococcus faecalis bacteremia or bacteremia without an obvious infection source. The goal is to explore how commensal bacteria may shift toward pathogenic behavior and contribute to endocarditis. Participants are on antibiotics started within 48 hours and are grouped based on the presence or absence of an identifiable entry point for infection. The study is centered at CHU de Clermont-Ferrand in France and does not specify a traditional randomized treatment phase. Findings may illuminate mechanisms of virulence and inform future therapeutic strategies.
Why it matters
Potential benefit: Understanding the pathways of virulence could lead to improved prevention and treatment strategies for EFIE in the future.
How similar studies have gone: Other studies have investigated bacterial virulence and bacteremia pathways, but this specific bridging of commensal to pathogenic mechanisms in EFIE is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients aged 18 years and older; * Capable of giving informed consent; * Affiliated with a social security system; * Hospitalized with at least one positive blood culture for Enterococcus faecalis, without an obvious clinical entry point after physical examination and initial routine investigations (BIEF group); * Hospitalized for another bacteremia, without an obvious clinical entry point after initial routine investigations (Control group); * Receiving antibiotic therapy that was started less than 48 hours ago Exclusion Criteria: * Refusal to participate in the study; * Pregnant or breastfeeding women; * Individuals under guardianship, curatorship, deprived of liberty, or under judicial protection; * Antibiotic therapy for the current infectious episode started more than 48 hours prior to inclusion.
Where it's running
-
CHU de Clermont-Ferrand
Clermont-Ferrand, France, France Recruiting
Study contacts
- Principal investigator: Magali VIDAL — University Hospital, Clermont-Ferrand
- Study coordinator: Lise Laclautre
- Email: promo_interne_drci@chu-clermontferrand.fr
- Phone: 334.73.754.963
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.