Frailty and Prognosis in Adults 75+ with Acute Coronary Syndrome
Official title: Investigation of Clinical Characteristics, Frailty, and Predictors of In-Hospital and Six-Month Prognosis in Hospitalized Patients Aged 75 Years and Older With Acute Coronary Syndrome
Run by Clinical Center Niš · NCT07366684 · Data updated 2026-11-12
This study will see if frailty plus admission data can better predict complications and death in people aged 75 and older with ACS.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 75 Years and up |
| Sex | All |
| Enrollment | 550 (estimated) |
| Sponsor | Clinical Center Niš Academic / other |
| Locations | 1 site (Niš) |
| Status | Recruiting |
| Started | May 13, 2026 |
| Main results expected | March 2027 |
| Study ends | September 2027 |
| Registry record updated | May 15, 2026 |
| Trial ID | NCT07366684 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are patients aged 75 or older admitted for STEMI, NSTEMI, or unstable angina at Clinical Center Niš, with prospective participants able to consent.
✕Probably not a fit
Patients who are not frail or those not treated with ACS-focused strategies may derive less direct benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study has retrospective and prospective parts to understand how frailty and other admission factors relate to outcomes in elderly ACS patients. Researchers will compare frailty scores and standard risk tools (TIMI, GRACE, Syntax) and look at differences between PCI and conservative treatment. Data will come from medical records and new patient assessments, with follow-up during hospitalization and for six months post-discharge. Findings aim to support more personalized treatment decisions for older adults with ACS.
Why it matters
Potential benefit: If successful, the study could improve risk prediction and guide treatment choices for elderly ACS patients.
How similar studies have gone: Prior research has shown frailty can influence outcomes in older cardiac patients, but this study adds prospective frailty assessment specifically at admission.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age ≥ 75 years * Diagnosis of acute coronary syndrome (STEMI, NSTEMI, or unstable angina) * Hospitalization in a tertiary care center (University Clinical Center Niš) * For prospective cohort: signed informed consent Exclusion Criteria: * Refusal to provide informed consent (prospective cohort) * Missing or incomplete medical documentation (retrospective cohort)
Where it's running
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Clinical Center Niš
Niš, Serbia Recruiting
Study contacts
- Study coordinator: Svetlana Apostolović
- Email: drapostolovic@gmail.com
- Phone: +381631094144
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.