Clinical trial Recruiting at 1 site Observational Ages 75 and up

Frailty and Prognosis in Adults 75+ with Acute Coronary Syndrome

Official title: Investigation of Clinical Characteristics, Frailty, and Predictors of In-Hospital and Six-Month Prognosis in Hospitalized Patients Aged 75 Years and Older With Acute Coronary Syndrome

Run by Clinical Center Niš · NCT07366684 · Data updated 2026-11-12

This study will see if frailty plus admission data can better predict complications and death in people aged 75 and older with ACS.

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Quick facts

Study typeObservational
Ages75 Years and up
SexAll
Enrollment550 (estimated)
SponsorClinical Center Niš
Academic / other
Locations1 site (Niš)
StatusRecruiting
StartedMay 13, 2026
Main results expectedMarch 2027
Study endsSeptember 2027
Registry record updatedMay 15, 2026
Trial IDNCT07366684 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are patients aged 75 or older admitted for STEMI, NSTEMI, or unstable angina at Clinical Center Niš, with prospective participants able to consent.

Probably not a fit

Patients who are not frail or those not treated with ACS-focused strategies may derive less direct benefit.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study has retrospective and prospective parts to understand how frailty and other admission factors relate to outcomes in elderly ACS patients. Researchers will compare frailty scores and standard risk tools (TIMI, GRACE, Syntax) and look at differences between PCI and conservative treatment. Data will come from medical records and new patient assessments, with follow-up during hospitalization and for six months post-discharge. Findings aim to support more personalized treatment decisions for older adults with ACS.

Why it matters

Potential benefit: If successful, the study could improve risk prediction and guide treatment choices for elderly ACS patients.

How similar studies have gone: Prior research has shown frailty can influence outcomes in older cardiac patients, but this study adds prospective frailty assessment specifically at admission.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Age ≥ 75 years
* Diagnosis of acute coronary syndrome (STEMI, NSTEMI, or unstable angina)
* Hospitalization in a tertiary care center (University Clinical Center Niš)
* For prospective cohort: signed informed consent

Exclusion Criteria:

* Refusal to provide informed consent (prospective cohort)
* Missing or incomplete medical documentation (retrospective cohort)

Where it's running

  • Clinical Center Niš
    Niš, Serbia
    Recruiting

Study contacts

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How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.