Fertility-sparing therapy for early-stage grade 2 endometrial cancer

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This multi-center, prospective, randomized trial compares monotherapy with oral medroxyprogesterone acetate to a combination regimens for women with endometrioid adenocarcinoma grade 2 who wish to preserve fertility. Eligibility is limited to patients with tumors confined to the endometrium (IA) and age 45 or younger. Outcomes include cancer control and pregnancy-related results after fertility-sparing therapy. The study is conducted at Peking University People’s Hospital and involves hospital and outpatient records to track efficacy and safety. The aim is to identify which regimen offers the best balance of oncologic safety and fertility potential.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Endometrioid adenocarcinoma G2, diagnosis by pathological.
* The lesion is limited to the endometrium.
* FIGO (2009) staging is IA.
* Age less than 45.
* Strongly request to preserve fertility.
* Sign informed consent.

Exclusion Criteria:

* The tumor has invaded the muscle layer.
* FIGO (2009) stage IB or higher.
* Endometrioid adenocarcinoma G1, G3, or non-endometrioid cancer
* There are malignant tumors in other systems.
* Have contraindications for conservative treatment or drug use.
* Have been judged by the researcher to be unsuitable for childbearing.

Where it's running

• Peking University People's Hospital
  Beijing, Beijing Municipality, China Recruiting

Study contacts

• Study coordinator: Yiqin Wang
• Email: emily_wang92@163.com
• Phone: 008688324380

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.