Fertility-sparing therapy for early-stage endometrial cancer

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial aims to evaluate the feasibility and outcomes of fertility-sparing therapy in patients with Stage IA endometrial adenocarcinoma, specifically those with less than 1/2 myometrial invasion. The study will involve 57 participants, comparing those with myometrial invasion to those without, to assess the potential for extending fertility-sparing treatment indications. Follow-up assessments will occur every 3-6 months for up to five years, focusing on complete remission rates, recurrence rates, and pregnancy outcomes. The primary goal is to determine the complete remission rate after 9 months of treatment.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Stage IA (FIGO 2009) ;
* Pathological diagnosis: endometrial adenocarcinoma G1-G2;
* MRI or ultrasound: tumor limited to endometrium or invading less than 1/2 of myometrium；
* 18 years old ≤ Age ≤ 45 years old;
* With a strong desire for fertility preservation；
* Sign the informed consent.

Exclusion Criteria:

* Complicated with any other malignancy；
* Contraindications to conservative treatment；
* Contraindications to progestin use;
* Contraindications to pregnancy, or judged by the researcher to be unfit for pregnancy or delivery.

Where it's running

• Peking University People's Hosoital
  Beijing, Beijing Municipality, China Recruiting

Study contacts

• Study coordinator: Jianliu Wang, Professor
• Email: wangjianliu1203@163.com
• Phone: 0086-010-88324381

Similar studies

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.