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Clinical trial Recruiting at 2 sites Interventional Ages 18 and up

Fermented plant-based diet for gut health and colitis

Official title: Fermented Vegan Optimized Diet in Health and Colitis

Run by Region Skane · NCT06696222 · Data updated 2026-11-12

This project will test whether a fermented, plant-based (vegan) diet improves gut barrier function and symptoms in people with ulcerative colitis or Crohn's disease and in healthy volunteers.

Quick facts

Study typeInterventional
Ages18 Years and up
SexAll
Enrollment240 (estimated)
SponsorRegion Skane
Academic / other
Locations2 sites (Malmö and 1 other locations)
StatusRecruiting
StartedNovember 18, 2024
Main results expectedDecember 31, 2026
Study endsDecember 31, 2027
Registry record updatedAugust 21, 2026
Trial IDNCT06696222 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are adults with ulcerative colitis or Crohn's disease who have not had extensive bowel surgery, as well as healthy adults without chronic illnesses or regular medications, and all participants must not have used antibiotics in the past month.

Probably not a fit

People who recently took antibiotics, have had extensive bowel surgery, have other chronic diseases requiring medication, or have severe unstable IBD are unlikely to receive benefit from this protocol.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional trial compares a fermented, plant-based diet (including vegetarian yogurt and meat alternatives) with an ordinary meat-containing diet and placebo products in both healthy volunteers and people with IBD (ulcerative colitis or Crohn's disease). Participants follow the assigned diet for a set period while investigators collect stool, blood, and clinical data to measure mucus barrier integrity, microbiota composition, and short-chain fatty acid production. Key exclusions include antibiotic use in the past month and, for IBD participants, previous extensive bowel surgery. The trial aims to see if replacing processed animal products with fermented plant-based alternatives increases mucus production, reduces bacterial translocation, and improves symptoms.

Why it matters

Potential benefit: If successful, the diet could strengthen the gut mucus barrier, boost beneficial microbiome metabolites like short-chain fatty acids, and reduce intestinal inflammation and symptoms for people with IBD.

How similar studies have gone: Smaller studies and observational data suggest high-fiber and fermented foods can modify the microbiome and sometimes improve symptoms, but large controlled trials in IBD are limited and results have been mixed.

Who can join: the full rules

Show full inclusion / exclusion criteria 
Inclusion Criteria:

* Healthy volunteers in two groups
* IBD in two groups (ulcerative colitis or Crohn's disease)

Exclusion Criteria:

* For healthy any disease requiring medication
* For IBD previous extensive operation
* For both antibiotics the past month

Where it's running

  • Dept of Gastroenterology
    Malmö, Sweden     Recruiting
  • Dept of Gastroenterology
    Malmö, Sweden     Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
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Inflammatory Bowel Disease (IBD) 41Region Skane 82
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.