Feasibility of MR-Informed Adaptive Marker-less SBRT for Localized Prostate Cancer in Patients with Bilateral Hip Prostheses

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional study examines a low-field MR-guided adaptive marker-less SBRT approach for definitive treatment of localized prostate cancer in men with bilateral hip prostheses. Patients must be eligible for SBRT per multidisciplinary guidance, have bilateral MR-safe or MR-conditional hip implants, and meet performance status and consent criteria. The method uses MRI to adapt treatment in real time without implanted fiducial markers, aiming to improve precision while accommodating implants. The study emphasizes safety, feasibility, and initial effectiveness signals in this technically challenging population. No phase designation is provided for this feasibility exploration.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Diagnosis of localized prostate cancer suitable for definitive SBRT based on a multidisciplinary tumour board recommendation and / or clinical practice guideline.
* Presence of bilateral hip prostheses labeled as MR safe or MR-conditional.
* ECOG performance status ≤ 2.
* Signed informed consent.
* Age ≥18 years -

Exclusion Criteria:

* Large body size that would not fit into the MRI-simulator bore
* Hip prosthesis that are labeled as MR unsafe;
* Contraindications to MRI including but not limited to:

  * Claustrophobia unmanageable by sedation
  * Electronic devices such as pacemakers, defibrillators, deep brain stimulators, cochlear implants that are labeled as MR unsafe, electronic devices labeled as MR safe or MR conditional are not a contraindication;
  * Metallic foreign body in the eye or aneurysm clips in the brain;
* Clinically significant concomitant diseases that would interfere with the study (e.g. hepatic dysfunction, cardiovascular disease).
* Inability to follow the procedures of the study, e.g. due to language problems, psychological disorders, dementia, etc.
* Enrolment of the investigator, his/her family members, employees and other dependent persons.

Where it's running

• University Hospital Zurich, Department of Radio-Oncology
  Zurich, Canton of Zurich, Switzerland Recruiting

Study contacts

• Principal investigator: Matthias Guckenberger, Prof. Dr. med. — University of Zurich
• Study coordinator: Matthias Guckenberger, Prof. Dr. med.
• Email: Matthias.Guckenberger@usz.ch
• Phone: +41442553566

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.