Eye Movement Intervention with Different Memory Reactivation Procedures for Intrusive Traumatic Memories

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This randomized trial compares several memory-related tasks paired with eye movements to see which best reduces the frequency and distress of intrusive memories in individuals with PTSD. The study is conducted online, collecting data remotely and using standardized procedures for memory reactivation and eye movement tasks. Participants are assigned to active conditions that pair trauma memory recall with eye movements or neutral memory recall with eye movements, and outcomes include intrusive-memory frequency, PTSD symptoms, acceptability, distress, and safety. Discontinuation conditions and data handling for those who stop the intervention are predefined. Optional follow-ups may provide descriptive feasibility and safety information but will not influence the main efficacy analyses.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Meet DSM-5 PTSD Criterion A, such as exposure to actual or threatened death, serious injury, or sexual violence; have experienced one or more traumatic events.
2. Experienced five or more trauma-related intrusive memories during the baseline week.
3. Have internet access and access to a personal computer suitable for completing the online study tasks.
4. Have normal or corrected-to-normal vision and be able to complete computerized visual and eye movement tasks.
5. Be willing to provide informed consent, able to complete study procedures, and able to be contacted by the study team.

Exclusion Criteria:

1. Have fewer than five trauma-related intrusive memories during the baseline week.
2. Have a current or past psychotic disorder, current manic episode, severe obsessive-compulsive disorder, severe personality disorder, or another severe psychiatric condition judged to interfere with study participation, adherence, or safety.
3. Have current acute suicidal ideation or behavior, significant risk of harm to self or others, or any condition requiring urgent clinical intervention.
4. Have current severe substance use disorder or severe substance dependence judged to interfere with study participation or safety.
5. Have a current organic disorder, neurological condition, history of epilepsy or seizures, significant brain injury, or other medical condition judged to interfere with safe participation or completion of the computerized visual or eye movement tasks.
6. Have visual impairment or other condition that prevents completion of the computerized visual or eye movement tasks.
7. Current participation in another intervention study or current treatment judged by the research team to interfere with study participation, safety, or outcome assessment.

Where it's running

• School of Psychology, Shaanxi Normal University
  Xi'an, Shaanxi, China Recruiting

Study contacts

• Study coordinator: Zhu Zijian
• Email: zhuzijian0203@snnu.edu.cn
• Phone: +86 13572494696

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.