Exploring tumor stiffness and adhesion in gliomas using magnetic resonance elastography
Comprehensive Assessment of Tumor Stiffness and Adhesion in Glioma Using Magnetic Resonance Elastography: A Prospective Study
This study is testing whether measuring the stiffness of glioma tumors with a special imaging technique can help doctors understand their characteristics better and improve treatment for patients.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 100 (estimated) |
| Ages | 18 Years to 80 Years |
| Sex | All |
| Sponsor | Shengjing Hospital Academic / other |
| Locations | 1 site (Shenyang, Liaoning) |
| Trial ID | NCT05990244 on ClinicalTrials.gov |
What this trial studies
This study investigates the relationship between tumor stiffness and adhesion in gliomas through the use of Magnetic Resonance Elastography (MRE). By employing preoperative MRE and intraoperative neuronavigation, the research aims to correlate tumor mechanical properties with molecular and genetic characteristics. Comprehensive molecular pathology analysis will follow tissue sample collection during surgery. The goal is to enhance clinical decision-making and personalize treatment approaches for glioma patients based on the findings.
Who should consider this trial
Good fit: Ideal candidates for this study are patients scheduled for glioma resection surgery.
Not a fit: Patients with metallic implants, severe claustrophobia, or those who cannot tolerate MRE may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved diagnostic accuracy and personalized treatment strategies for glioma patients.
How similar studies have performed: Other studies utilizing MRE for tumor characterization have shown promising results, indicating potential for success in this approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. age older than 18 years 2. Karnofsky performance status higher than 60 3. with written informed consent 4. MRE performed within one week before surgery 5. tumor diameter \> 2 cm Exclusion Criteria: 1. previous treatment for glioma 2. inability to complete MRE due to intolerance (e.g., vibration-related discomfort or claustrophobia) 3. completed MRE with suboptimal wave image quality (e.g., motion artifacts or inad-equate wave amplitude) 4. failure to proceed with surgery after MRE 5. missing IDH results
Where this trial is running
Shenyang, Liaoning
- Shengjing Hospital — Shenyang, Liaoning, China (Recruiting)
Study contacts
- Principal investigator: Yu Shi, MD — Shengjing Hospital
- Study coordinator: Yu Shi, MD
- Email: 18940259980@163.com
- Phone: +86 189 4025 9980
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.