Exploring the link between sleep apnea and cognitive function in individuals with mild cognitive impairment

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study investigates the relationship between obstructive sleep apnea (OSA) and cognitive function in individuals diagnosed with mild cognitive impairment (MCI) or subjective cognitive impairment. It aims to assess how sleep-related symptoms and apnea episodes may contribute to neurocognitive decline. Participants will undergo a Home Sleep Apnea Test (HSAT) to evaluate their sleep patterns and apnea severity. The findings are expected to provide insights that could inform future interventions targeting sleep as a modifiable risk factor for cognitive impairment.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Aged 18 years and above
* Clinical diagnosis of mild cognitive impairment (MCI) based on Petersen's criteria. The criteria include the following: (1) memory problems, (2) objective memory disorder, (3) absence of other cognitive disorders or repercussions on daily life, (4) normal general cognitive function and (5) absence of dementia OR,
* Diagnosis of subjective cognitive impairment, based on the subject's own complaint of cognitive impairment but with an unremarkable assessment of the Hong Kong version of Montreal Cognitive Assessment scores
* Able to speak and read Chinese
* Adequate visual and auditory to perform a cognitive test

Exclusion Criteria:

* Diagnosed psychiatric illness with or without medication, e.g. major depressive disorder.
* Other clear organic causes of cognitive impairment, e.g. old stroke, brain tumour, dementia with Lewy body, Parkinson's disease, normal pressure hydrocephalus, neurosyphilis, autoimmune encephalitis, substance abuse, history of alcohol abuse.
* Diagnosis of major unstable illness or cancer on active treatment
* Unable to perform Home Sleep Apnea Test
* Those patients who require legal guardians

Where it's running

• Queen Mary Hospital
  Hong Kong, Hong Kong Recruiting

Study contacts

• Principal investigator: Sau Man Mary Ip, MD — School of Clinical Medicine, The University of Hong Kong
• Study coordinator: Sau Man Mary Ip, MD
• Email: msmip@hku.hk
• Phone: 2255 5885

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.