Exploring the link between sleep apnea and cognitive function in individuals with mild cognitive impairment
Exploring the Association of Sleep Apnea With Cognitive Function in Subjects With Subjective or Mild Cognitive Impairment
This study is testing how sleep apnea affects thinking and memory in people with mild cognitive impairment to see if improving sleep could help their brain health.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 250 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | The University of Hong Kong Academic / other |
| Locations | 1 site (Hong Kong) |
| Trial ID | NCT06089096 on ClinicalTrials.gov |
What this trial studies
This observational study investigates the relationship between obstructive sleep apnea (OSA) and cognitive function in individuals diagnosed with mild cognitive impairment (MCI) or subjective cognitive impairment. It aims to assess how sleep-related symptoms and apnea episodes may contribute to neurocognitive decline. Participants will undergo a Home Sleep Apnea Test (HSAT) to evaluate their sleep patterns and apnea severity. The findings are expected to provide insights that could inform future interventions targeting sleep as a modifiable risk factor for cognitive impairment.
Who should consider this trial
Good fit: Ideal candidates include adults aged 18 and above with a clinical diagnosis of mild cognitive impairment or subjective cognitive impairment who can communicate in Chinese.
Not a fit: Patients with diagnosed psychiatric illnesses or other clear organic causes of cognitive impairment may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved strategies for managing cognitive decline in patients with sleep apnea.
How similar studies have performed: Previous studies have indicated that obstructive sleep apnea may be a modifiable risk factor for cognitive decline, suggesting potential for success in this area.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Aged 18 years and above * Clinical diagnosis of mild cognitive impairment (MCI) based on Petersen's criteria. The criteria include the following: (1) memory problems, (2) objective memory disorder, (3) absence of other cognitive disorders or repercussions on daily life, (4) normal general cognitive function and (5) absence of dementia OR, * Diagnosis of subjective cognitive impairment, based on the subject's own complaint of cognitive impairment but with an unremarkable assessment of the Hong Kong version of Montreal Cognitive Assessment scores * Able to speak and read Chinese * Adequate visual and auditory to perform a cognitive test Exclusion Criteria: * Diagnosed psychiatric illness with or without medication, e.g. major depressive disorder. * Other clear organic causes of cognitive impairment, e.g. old stroke, brain tumour, dementia with Lewy body, Parkinson's disease, normal pressure hydrocephalus, neurosyphilis, autoimmune encephalitis, substance abuse, history of alcohol abuse. * Diagnosis of major unstable illness or cancer on active treatment * Unable to perform Home Sleep Apnea Test * Those patients who require legal guardians
Where this trial is running
Hong Kong
- Queen Mary Hospital — Hong Kong, Hong Kong (Recruiting)
Study contacts
- Principal investigator: Sau Man Mary Ip, MD — School of Clinical Medicine, The University of Hong Kong
- Study coordinator: Sau Man Mary Ip, MD
- Email: msmip@hku.hk
- Phone: 2255 5885
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.