Investigating the link between sleep apnea and cognitive decline in older adults

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study examines the relationship between obstructive sleep apnea (OSA) and neurocognitive decline in individuals aged 50 to 80 with mild cognitive impairment or subjective cognitive complaints. It aims to determine if OSA is a contributing factor to cognitive decline and whether treatment with Continuous Positive Airway Pressure (CPAP) can mitigate this decline. Participants will undergo baseline PET-MRI brain scans to assess amyloid accumulation and neurocognitive status. The study seeks to identify modifiable factors that could improve cognitive function in affected individuals.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Aged 50 - 80 years
* Diagnosis of mild cognitive impairment based on Peterson's criteria.
* Diagnosis of subjective cognitive impairment, based on the subjective complaint of cognitive impairment, but with an unremarkable assessment of the Hong Kong version of Montreal cognitive Assessment scores
* Able to speak and read Chinese
* Adequate visual and auditory to perform a cognitive test
* Subjects with moderate-severe OSA or No OSA (diagnosis based on sleep study) would be invited for baseline PET-MRI brain scan

Exclusion Criteria:

* Diagnosed psychiatric illness with or without medication, e.g. major depressive disorder.
* Other clear organic causes of cognitive impairment, e.g. vascular cognitive impairment, brain tumour, dementia with Lewy body, mild cognitive impairment with Lewy body, Parkinson's disease, normal pressure hydrocephalus, neurosyphilis, autoimmune encephalitis, substance abuse, history of alcohol abuse.
* Diagnosis of cancer on active treatment
* Contraindications to PET-CT or MRI brain scan (excluded for neuroimaging studies)

Where it's running

• Queen Mary Hospital
  Hong Kong, Hong Kong Recruiting

Study contacts

• Principal investigator: Mary SM Ip, MD — School of Clinical Medicine, The University of Hong Kong
• Study coordinator: Sau Man Mary Ip, MD
• Email: msmip@hku.hk
• Phone: 2255 5885

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.