Exploring the effects of positioning and binding on lung and muscle health in ARDS patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the impact of different ventilatory strategies, including prone positioning and thoracoabdominal binding, on lung and muscle function in patients with acute respiratory distress syndrome (ARDS) who are transitioning from controlled to spontaneous breathing. It consists of three steps: a multimodal assessment of muscle and lung function, a crossover trial comparing various ventilatory approaches, and a randomized controlled trial evaluating the effects on lung inflammation and injury biomarkers. The goal is to identify methods that can reduce complications associated with prolonged mechanical ventilation.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adult ARDS patients with moderate-severe ARDS on controlled protective mechanical ventilation for more than 3 days
* Stable hemodynamics
* Level of consciousness enough to initiate spontaneous breathing

Exclusion Criteria:

* Unstable hemodynamics
* Tracheostomy
* Abnormal level of consciousness
* Central nervous system injury
* Esophageal varices
* Pregnancy
* Contraindications for installation of electrical impedance tomography or ultrasound assessments

Where it's running

• Hospital Clínico Universidad de Chile
  Independencia, Chile Recruiting

Study contacts

• Principal investigator: Rodrigo Cornejo — University of Chile
• Study coordinator: Rodrigo Cornejo
• Email: racornej@gmail.com
• Phone: +56229788264

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.