Exploring how music training can improve brain function in schizophrenia
White Matter Plasticity in Schizophrenia
This study tests whether playing a music video game can help improve brain function in young people with schizophrenia by changing the way their brain is wired.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 36 (estimated) |
| Ages | 15 Years to 45 Years |
| Sex | All |
| Sponsor | University of Maryland, Baltimore Academic / other |
| Locations | 2 sites (Catonsville, Maryland and 1 other locations) |
| Trial ID | NCT06641297 on ClinicalTrials.gov |
What this trial studies
This study investigates the impact of music training on white matter plasticity in individuals diagnosed with schizophrenia spectrum disorders. It focuses on understanding how playing a mock musical instrument may help correct white matter deficits associated with cognitive impairments in these patients. Participants aged 15-45 will engage in a music video game designed to stimulate changes in brain structure. The study aims to uncover the mechanisms behind these changes and their potential benefits for cognitive processing speed.
Who should consider this trial
Good fit: Ideal candidates include individuals aged 15-45 with a diagnosis of schizophrenia or related disorders who can provide informed consent.
Not a fit: Patients with contraindications to MRI or those with medical conditions that limit hand use may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could enhance cognitive function and quality of life for patients with schizophrenia.
How similar studies have performed: While the specific approach of using music training is novel, similar studies have shown promise in enhancing cognitive function through various forms of training.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Diagnosis of schizophrenia, schizoaffective disorder, schizophreniform disorder, or psychosis NOS * age 15-45 * able to provide informed consent Exclusion Criteria: * contraindications to MRI (metal implants, claustrophobia) * medical condition that limits use of hands (ie, arthritis) * Active or recent (within 6 months) substance use disorder other than nicotine
Where this trial is running
Catonsville, Maryland and 1 other locations
- Maryland Psychiatric Research Center — Catonsville, Maryland, United States (Recruiting)
- University of Maryland Baltimore - Maryland Psychiatric Research Center — Catonsville, Maryland, United States (Not_yet_recruiting)
Study contacts
- Study coordinator: Joshua J Chiappelli, MD
- Email: jchiappe@som.umaryland.edu
- Phone: 4104026827
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.