Exploring how music training can improve brain function in schizophrenia
Official title: White Matter Plasticity in Schizophrenia
Run by University of Maryland, Baltimore · NCT06641297 · Data updated 2026-11-12
This study tests whether playing a music video game can help improve brain function in young people with schizophrenia by changing the way their brain is wired.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 15 Years to 45 Years |
| Sex | All |
| Enrollment | 36 (estimated) |
| Sponsor | University of Maryland, Baltimore Academic / other |
| Locations | 2 sites (Catonsville, Maryland and 1 other locations) |
| Status | Recruiting |
| Started | January 2, 2025 |
| Main results expected | December 31, 2026 |
| Study ends | December 31, 2026 |
| Registry record updated | February 20, 2026 |
| Trial ID | NCT06641297 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include individuals aged 15-45 with a diagnosis of schizophrenia or related disorders who can provide informed consent.
✕Probably not a fit
Patients with contraindications to MRI or those with medical conditions that limit hand use may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study investigates the impact of music training on white matter plasticity in individuals diagnosed with schizophrenia spectrum disorders. It focuses on understanding how playing a mock musical instrument may help correct white matter deficits associated with cognitive impairments in these patients. Participants aged 15-45 will engage in a music video game designed to stimulate changes in brain structure. The study aims to uncover the mechanisms behind these changes and their potential benefits for cognitive processing speed.
Why it matters
Potential benefit: If successful, this approach could enhance cognitive function and quality of life for patients with schizophrenia.
How similar studies have gone: While the specific approach of using music training is novel, similar studies have shown promise in enhancing cognitive function through various forms of training.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Diagnosis of schizophrenia, schizoaffective disorder, schizophreniform disorder, or psychosis NOS * age 15-45 * able to provide informed consent Exclusion Criteria: * contraindications to MRI (metal implants, claustrophobia) * medical condition that limits use of hands (ie, arthritis) * Active or recent (within 6 months) substance use disorder other than nicotine
Where it's running
-
Maryland Psychiatric Research Center
Catonsville, Maryland, United States Recruiting -
University of Maryland Baltimore - Maryland Psychiatric Research Center
Catonsville, Maryland, United States Not yet recruiting
Study contacts
- Study coordinator: Joshua J Chiappelli, MD
- Email: jchiappe@som.umaryland.edu
- Phone: 4104026827
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.