Exploring genetic and immune factors in heart failure

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to investigate the relationship between inflammatory markers and heart failure with preserved ejection fraction, focusing on gender differences and advanced age. It will involve adult patients hospitalized for chronic heart failure, collecting clinical and demographic data from electronic health records. The study will document various clinical parameters, including comorbidities and NYHA class, to better understand the inflammatory state in these patients.

Why it matters

Who can join: the full rules

Inclusion criteria:

* Adult patients (age ≥18 years) with exacerbation of chronic heart failure with reduced or preserved ejection fraction,
* stable haemodynamic conditions, without the need for inotropic support at the time of admission to the ward,
* signature of the informed consent.

Exclusion criteria:

. age \<18 years;

* pregnancy;
* acute coronary syndromes;
* end-stage renal failure (clearance \<30 mL/min) or dialysis;
* ongoing sepsis;
* bed rest syndrome;
* any concomitant neoplasm,
* congenital and acquired immunodeficiencies (HIV, immunosuppressive drugs).

Where it's running

• Fondazione Policlinico Universitario A. Gemelli IRCCS, UOC Medicina Genarale e dell'Invecchiamento
  Rome, Lazio, Italy Recruiting
• IRCCS Casa Sollievo della Sofferenza
  San Giovanni Rotondo, Foggia, Italy Active not recruiting

Study contacts

• Principal investigator: Rossella Cianci — Fondazione Policlinico Universitario Agostino Gemelli IRCCS
• Study coordinator: Rossella Cianci
• Email: rossella.cianci@policlinicogemelli.it
• Phone: +390630154878

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.