Exercise with telehealth or walking programs for people with PRISm
Official title: Role of Exercise in Functional Capacity of Smokers and Subsequent Development of Chronic Obstructive Pulmonary Disease
Run by The University of Hong Kong · NCT07387432 · Data updated 2026-11-12
This project will test whether a telehealth-guided exercise program or a step-based walking program, together with smoking-cessation advice, helps people with PRISm stay stable or avoid developing COPD.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 90 (estimated) |
| Sponsor | The University of Hong Kong Academic / other |
| Locations | 1 site (Hong Kong) |
| Status | Recruiting |
| Started | July 14, 2025 |
| Main results expected | January 2027 |
| Study ends | January 2028 |
| Registry record updated | March 6, 2026 |
| Trial ID | NCT07387432 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults (≥18) who currently smoke or formerly smoked, are ambulatory, can give informed consent, and have spirometry showing PRISm (FEV1/FVC ≥ 0.7 and FEV1 < 80% predicted).
✕Probably not a fit
Non-smokers, people who cannot walk independently, those whose spirometry does not meet PRISm criteria, or those unable to attend required in-person assessments are unlikely to benefit from this protocol.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This open-label, randomized controlled trial enrolls smokers and ex-smokers with PRISm and randomizes them 1:1:1 to telehealth-guided exercise, a progressive walking step-goal program, or no exercise instruction. The active interventions last 26 weeks (telehealth sessions twice weekly; walking program with weekly step targets) with clinical follow-up through 52 weeks. All participants receive smoking cessation advice and serial assessments including spirometry, 6-minute walk test, symptom scores, and hospitalisation tracking at scheduled visits. The trial measures whether these exercise approaches change spirometric status, functional capacity, respiratory symptoms, and healthcare events over one year.
Why it matters
Potential benefit: If successful, these interventions could slow or prevent progression from PRISm to COPD and improve breathing, exercise capacity, and quality of life.
How similar studies have gone: Exercise and pulmonary rehabilitation have improved symptoms and function in COPD and telehealth delivery has shown promise, but randomized trials specifically targeting PRISm are limited.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age 18 or above * Smoker/ ex-smoker * Spirometry shows PRISm, with FEV1/FVC \>= 0.7 and FEV1 \<80% predicted * Ambulatory to walk * Able to give informed consent Exclusion Criteria: * Age below 18 * Non-smoker * Spirometry does not show PRISm/ unable to perform spirometry * Requires assistance for walking * Unable to give informed consent
Where it's running
-
The University of Hong Kong, Queen Mary Hospital
Hong Kong, China Recruiting
Study contacts
- Principal investigator: King Pui Florence Chan, MD — he University of Hong Kong, Queen Mary Hospital
- Study coordinator: King Pui Florence Chan, MD
- Email: kpfchan@hku.hk
- Phone: +852 22553741
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.