Exercise training's effects on gut health and blood pressure in adults with hypertension
Exercise Training Influences Gut Microbiota and Cardiovascular Health Through Inflammation Control in Adult Hypertensive Population: the MicroFit Study
NA · University of Bologna · NCT05967715
This study is testing whether a structured exercise program, along with probiotics, can improve gut health and lower blood pressure in adults with hypertension.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 75 (estimated) |
| Ages | 40 Years to 65 Years |
| Sex | All |
| Sponsor | University of Bologna (other) |
| Locations | 1 site (Bologna) |
| Trial ID | NCT05967715 on ClinicalTrials.gov |
What this trial studies
This study investigates how exercise training influences gut microbiota and cardiovascular health by controlling inflammation in adults with hypertension. Participants will engage in a structured exercise program while some will receive probiotics or a placebo to assess the combined effects on their gut health and blood pressure. The study aims to uncover the mechanisms linking physical activity, gut microbiota, and inflammation in hypertensive individuals. By understanding these relationships, the research seeks to provide insights into effective interventions for managing hypertension.
Who should consider this trial
Good fit: Ideal candidates are adults aged 40-65 with stable hypertension who are on controlled antihypertensive therapy.
Not a fit: Patients with conditions such as diabetes, heart failure, or recent serious health issues may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved management strategies for hypertension through lifestyle modifications and gut health optimization.
How similar studies have performed: While the relationship between exercise and gut microbiota has been explored, this specific approach focusing on hypertension is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Arterial hypertension\*; * Stable antihypertensive therapy in the last 2 months, with controlled blood pressure values; * Age 40-65 years; * Willing to sign the written informed consent; * Written and spoken Italian language comprehension. Exclusion Criteria: * Atrial fibrillation; * Diabetes mellitus either type I or II; * Active cancer; * Inflammatory bowel disease; * Heart failure NYHA class III to IV; * Recent antibiotic or probiotic treatment in the previous month for any reason; * Recent myocardial infarction or hospital admission for any other reason in the previous 6 months; * Any other condition that the medical doctor (MD) considers to contraindicate the participation in an exercise program of High intensity; * Pulmonary disease requiring oxygen therapy; * Relevant neurological condition impairing motor or cognitive function; * Severe depressive disorder; * Pregnancy.
Where this trial is running
Bologna
- University of Bologna — Bologna, Italy (RECRUITING)
Study contacts
- Study coordinator: Davide Agnoletti, PhD
- Email: davide.agnoletti2@unibo.it
- Phone: 00390512145597
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Hypertension, Microbiota, hypertension, gut microbiota, exercise training, physical activity, central hemodynamics, arterial stiffness