Exercise therapy for patients with glaucoma
Official title: High Intensity Interval Training in Patients With Glaucoma
Run by University of Basel · NCT06058598 · Data updated 2026-05-14
This study is no longer in our active list. It may have stopped recruiting or finished. The details below are as of 2026-05-14 and are kept for reference. Check ClinicalTrials.gov for its current status, or see similar studies below.
This study tests if a structured exercise program can help people with glaucoma feel better and slow down the disease compared to just receiving lifestyle advice.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 40 Years to 80 Years |
| Sex | All |
| Enrollment | 168 (estimated) |
| Sponsor | University of Basel Academic / other |
| Locations | 1 site (Basel) |
| Trial ID | NCT06058598 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults aged 40 to 75 with primary open-angle glaucoma, high tension glaucoma, or normal tension glaucoma who are in regular follow-up at the study centers.
✕Probably not a fit
Patients with very severe glaucoma, recent glaucoma surgery, or significant comorbidities such as life-threatening arrhythmia or cancer may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This multicenter study investigates the effects of high-intensity interval training on patients with primary open-angle glaucoma. Participants will be randomly assigned to either an intervention group, which will undergo a structured exercise program, or a control group receiving lifestyle counseling. The study aims to assess whether exercise can improve disease progression and enhance the quality of life for glaucoma patients. Follow-up assessments will occur at baseline, three months, and six months to evaluate the outcomes of the intervention.
Why it matters
Potential benefit: If successful, this approach could provide a novel non-pharmacological treatment option that improves the management of glaucoma.
How similar studies have gone: While the concept of using exercise for glaucoma treatment is novel, previous studies have shown positive effects of physical activity on vascular health, suggesting potential benefits.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Voluntary written informed consent of the participant has been obtained prior to any screening procedures * Patients with primary open angle glaucoma (POAG), high tension glaucoma (HTG) and normal tension glaucoma (NTG), aged 40 - 75 years * In regular follow-up in either of the two study centres Exclusion Criteria: * Patients having had glaucoma surgery within 6 months before start of the project * Patients with changes in topical medication or laser trabeculoplasty within 3 months before start of the project * Patients with very severe glaucoma (visual field mean deviation lower than -12Db) * Significant opacification of ocular media * Patients with life-threatening arrhythmia, signs of ischemia during CPET which preclude participation in an exercise trial * Patients with insulin treated diabetes, chronic obstructive pulmonary disease or cancer. * Patients doing ≥1 structured exercise training session per week or \>150min of exercise/week assessed via the following two questions: a. On average, how many days per week do you engage in moderate to vigorous physical activity (like brisk walking)? b. On average, how many minutes per day do you engage in physical activity at this level? Calculate the total weekly minutes of exercise by multiplying a times b. * Mental or physical limitation precluding participation in a high intensity exercise program
Where it's running
-
University of Basel, Department of Sport, Exercise & Health
Basel, Switzerland Recruiting
Study contacts
- Study coordinator: Henner Hanssen, Prof. Dr.
- Email: henner.hanssen@unibas.ch
- Phone: +41 61 207 47 46
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.