Exercise rehabilitation for wheelchair users with multiple sclerosis
Official title: Randomized Pilot Study Evaluating the Effect of a 6-Month Exercise Rehabilitation Program on Physical and Cognitive Function in Persons With MS Who Use Wheelchairs as a Primary Mobility Device
Run by University of Illinois Chicago · NCT06410261 · Data updated 2026-11-12
This study tests a personalized exercise program for wheelchair users with multiple sclerosis to see if it can help them feel stronger and improve their daily activities.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 24 (estimated) |
| Sponsor | University of Illinois Chicago Academic / other |
| Locations | 1 site (Chicago, Illinois) |
| Status | Recruiting |
| Started | April 29, 2024 |
| Main results expected | July 31, 2026 |
| Study ends | July 31, 2027 |
| Registry record updated | July 13, 2026 |
| Trial ID | NCT06410261 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include adults over 18 with a diagnosis of MS who use a wheelchair for mobility but can still walk at least 50 feet with an assistive device.
✕Probably not a fit
Patients who do not use a wheelchair as their primary mobility device or those unable to walk at least 50 feet will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study investigates a personalized exercise rehabilitation program designed for individuals with multiple sclerosis (MS) who primarily use wheelchairs for mobility. The program aims to enhance muscular strength and improve physical function, potentially reducing fatigue associated with daily activities. Participants will engage in a 6-month exercise regimen, and outcomes will be assessed in terms of physical function, health-related quality of life, and cognitive performance. The research seeks to fill a gap in existing literature regarding exercise interventions for this specific population.
Why it matters
Potential benefit: If successful, this program could significantly improve the physical function and quality of life for wheelchair users with MS.
How similar studies have gone: While there is limited research specifically targeting wheelchair users with MS, similar exercise rehabilitation programs have shown success in other chronic conditions, suggesting potential for positive outcomes.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * diagnosis of MS * age above 18 years * no relapse within last 30 days * use of wheelchair for mobility in the community * ability to walk at least 50 feet (or 65 steps) using an assistive device * low risk for contraindications of physical activity indicated by no more than a single "yes" * response on the Physical Activity Readiness Questionnaire (PAR-Q) * willingness to complete the assessments and undergo randomization Exclusion Criteria: * no diagnosis of MS * less than 18 years of age * not relapse-free within the last 30 days * no use of wheelchair as primary mobility device * no ability to walk for at least 50 feet (or 65 steps) * high risk for contraindications based on more than a single "yes" response on the PAR-Q * not willing to complete the testing procedures and undergo randomization
Where it's running
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University of Illinois at Chicago
Chicago, Illinois, United States Recruiting
Study contacts
- Principal investigator: Enrico Benedetti, MD — University of Illinois Chicago
- Study coordinator: Enrico Benedetti, MD
- Email: enrico@uic.edu
- Phone: 312-355-1493
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.