Exercise program to help cancer patients during chemotherapy

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This research evaluates the feasibility of a 16-week virtually supervised aerobic and resistance exercise program for patients with ovarian or endometrial cancer undergoing first-line chemotherapy. The study compares an exercise group to a control group to assess improvements in lower extremity function, chemotherapy-induced peripheral neuropathy (CIPN), and inflammatory blood markers. Participants will engage in home-based exercise sessions via Zoom, while the control group will perform stretching exercises. The study aims to enroll approximately 30 participants.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Newly diagnosed patients with stages III-IV ovarian or endometrial cancer
* Receiving first-line carboplatin and paclitaxel chemotherapy after surgery
* ≥18 years, children under the age of 18 will be excluded due to rarity of disease
* Physician's clearance to participate in moderate-vigorous intensity exercise
* Able to read, write, and understand English
* Ability to understand and the willingness to sign an informed consent document
* Willing to undergo two venous blood draws for the study

Exclusion Criteria:

* Pre-existing musculoskeletal, neurological, or cardiorespiratory conditions, as determined by the treating oncologist
* Participants with uncontrolled intercurrent illness, as determined by the treating oncologist
* Participants with psychiatric illness/social situations that would limit compliance with study requirements, as determined by the treating oncologist
* Participants who have received prior chemotherapy for cancer treatment (e.g. taxanes for breast cancer)

Where it's running

• Dana Farber Cancer Institute
  Boston, Massachusetts, United States Recruiting

Study contacts

• Principal investigator: Christina Dieli-Conwright, PhD — Dana-Farber Cancer Institute
• Study coordinator: Christina Dieli-Conwright, PhD
• Email: ChristinaM_Dieli-Conwright@dfci.harvard.edu
• Phone: (617) 582-8321

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.