Examining how exercise affects metabolism and energy use

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates the impact of aerobic exercise on obesity in sedentary adults. Participants will engage in supervised running sessions five times a week for 12 weeks, with metabolic and anthropometric measurements taken before, immediately after, and 8 weeks post-intervention. The study aims to understand how exercise influences total energy expenditure and the mechanisms behind energy compensation that may limit weight loss. By analyzing these factors, researchers hope to provide insights into effective exercise interventions for obesity treatment.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Sedentary individuals
* BMI ≥ 18.5 kg/m2

Exclusion Criteria:

* Individuals who have undergone major surgery in the past 6 months (excluding tooth extraction);
* Individuals on long-term medication;
* Individuals with metabolic and cardiovascular diseases such as diabetes, hypoglycemia, and hypertension;
* Individuals with exercise-related injuries, including joint diseases and fractures;
* Individuals diagnosed with infectious diseases such as HIV, tuberculosis, malaria, etc.;
* Individuals with mental and neurological disorders including anorexia nervosa;
* Individuals who have attempted weight loss or gain through various methods in the past three months;
* Individuals in preconception, pregnancy, and lactation periods;
* Individuals with autism and those with metal implants in their bodies.

Where it's running

• Shenzhen Institutes of Advanced Technology ,Chinese Academy of Sciences
  Shenzhen, Guangdong, China Recruiting

Study contacts

• Principal investigator: John R Speakman, PhD — Shenzhen Institutes of Advanced Technology ,Chinese Academy of Sciences
• Study coordinator: John R Speakman, PhD
• Email: j.speakman@abdn.ac.uk
• Phone: +8615810868669

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.