Examining how exercise affects metabolism and energy use
Metabolic Response of Sedentary Participants to a Long-term Exercise Intervention
This study tests how regular running can help overweight adults lose weight and understand how exercise affects their energy use.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 80 (estimated) |
| Ages | 18 Years to 40 Years |
| Sex | All |
| Sponsor | Shenzhen Institutes of Advanced Technology ,Chinese Academy of Sciences Academic / other |
| Locations | 1 site (Shenzhen, Guangdong) |
| Trial ID | NCT06923163 on ClinicalTrials.gov |
What this trial studies
This clinical trial investigates the impact of aerobic exercise on obesity in sedentary adults. Participants will engage in supervised running sessions five times a week for 12 weeks, with metabolic and anthropometric measurements taken before, immediately after, and 8 weeks post-intervention. The study aims to understand how exercise influences total energy expenditure and the mechanisms behind energy compensation that may limit weight loss. By analyzing these factors, researchers hope to provide insights into effective exercise interventions for obesity treatment.
Who should consider this trial
Good fit: Ideal candidates for this study are sedentary adults with a BMI of 18.5 kg/m2 or higher.
Not a fit: Patients with recent major surgeries, metabolic or cardiovascular diseases, or those on long-term medications may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to more effective exercise-based treatments for obesity, improving health outcomes for patients.
How similar studies have performed: Previous studies have indicated energy compensation effects from exercise, but this trial aims to explore these mechanisms in a controlled setting, making it a novel approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Sedentary individuals * BMI ≥ 18.5 kg/m2 Exclusion Criteria: * Individuals who have undergone major surgery in the past 6 months (excluding tooth extraction); * Individuals on long-term medication; * Individuals with metabolic and cardiovascular diseases such as diabetes, hypoglycemia, and hypertension; * Individuals with exercise-related injuries, including joint diseases and fractures; * Individuals diagnosed with infectious diseases such as HIV, tuberculosis, malaria, etc.; * Individuals with mental and neurological disorders including anorexia nervosa; * Individuals who have attempted weight loss or gain through various methods in the past three months; * Individuals in preconception, pregnancy, and lactation periods; * Individuals with autism and those with metal implants in their bodies.
Where this trial is running
Shenzhen, Guangdong
- Shenzhen Institutes of Advanced Technology ,Chinese Academy of Sciences — Shenzhen, Guangdong, China (Recruiting)
Study contacts
- Principal investigator: John R Speakman, PhD — Shenzhen Institutes of Advanced Technology ,Chinese Academy of Sciences
- Study coordinator: John R Speakman, PhD
- Email: j.speakman@abdn.ac.uk
- Phone: +8615810868669
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.