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Examining gut microbiota in patients with critical chronic diseases in China

A Multicentre Study on Features of the Gut Microbiota of Patients With Critical Chronic Diseases in China

Observational Zhujiang Hospital · NCT05638269

This study is trying to understand the gut bacteria of people with serious chronic diseases like cancer and high blood pressure to see how it differs from healthy individuals.

Quick facts

Study typeObservational
Enrollment12000 (estimated)
Ages18 Years to 75 Years
SexAll
SponsorZhujiang Hospital Academic / other
Locations50 sites (Chaoyang, Beijing Municipality and 49 other locations)
Trial IDNCT05638269 on ClinicalTrials.gov

What this trial studies

This observational study aims to systematically characterize the gut microbiota of patients suffering from various critical chronic diseases, including different types of cancer and hypertension. By recruiting 500 patients for each disease and matching them with controls, the study will collect comprehensive demographic, lifestyle, and biological data, including feces, saliva, urine, and blood samples. The goal is to compare microbiome signatures across different regions and diseases, enhancing the understanding of microbial dysbiosis and its potential role in diagnostic models.

Who should consider this trial

Good fit: Ideal candidates are adults aged 18-75 with a confirmed diagnosis of one of the target diseases and residing in the study's geographic locations.

Not a fit: Patients with serious other medical conditions or those who have recently taken certain medications or supplements may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could lead to improved diagnostic models based on gut microbiota, potentially enhancing disease management for patients with critical chronic conditions.

How similar studies have performed: While studies on gut microbiota have shown promise, this multicentric approach focusing on critical chronic diseases is relatively novel and untested.

Eligibility criteria

Show full inclusion / exclusion criteria 
Inclusion Criteria:

1. aged 18-75 years;
2. living in the province where the hospital is located in the last three years;
3. with a medical diagnosis of one of the target diseases;
4. willing to provide written informed consent.

Exclusion Criteria:

1. female in pregnancy or lactation(unless the subject is pregnant women);
2. with medical diagnoses of other serious illnesses;
3. with a history of bariatric surgery or intestinal resection, except for appendectomy；
4. individual who was treated with drugs in the preceding 1 month, including antibiotics, metformin, statins, acid inhibitor, probiotics, and probiotics; individuals having consumed yogurt more than 3 times in the preceding 1 month; heavy drinkers who have consumed more than 4 taels of liquor or 1000ml of beer; frequent alcohol consumers who have drunk per week in the last month.

Where this trial is running

Chaoyang, Beijing Municipality and 49 other locations

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
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Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.