Clinical trial Recruiting at 1 site Observational Ages 18 and up

Examining environmental toxicant exposure in firefighters

Official title: Evaluate the Exposure to Toxicants Emitted During a Structural Fire Assessed by Urinary and Buccal Cell Biomarkers Found in Firefighters.

Run by Masonic Cancer Center, University of Minnesota · NCT05643014 · Data updated 2026-11-12

This study is trying to see how exposure to harmful chemicals during firefighting affects firefighters by collecting urine samples before and after they fight fires.

Quick facts

Study typeObservational
Ages18 Years and up
SexAll
Enrollment60 (estimated)
SponsorMasonic Cancer Center, University of Minnesota
Academic / other
Locations1 site (Minneapolis, Minnesota)
StatusRecruiting
StartedFebruary 1, 2020
Main results expectedDecember 31, 2026
Study endsDecember 31, 2027
Registry record updatedMarch 12, 2026
Trial IDNCT05643014 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates for this study are firefighters, both career and volunteer, who are over 18 years old and can provide consent.

Probably not a fit

Patients currently diagnosed with cancer or those who have used tobacco in the past year may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study collects biomarker samples from firefighters before and after exposure to combustion emissions during structural fires. The aim is to assess the levels of toxicants, specifically focusing on substances like PAH, 1-HOP, PheT, and SPMA. Participants will provide urine samples to evaluate their exposure to these harmful substances, contributing to a better understanding of the health risks associated with firefighting. The study is designed to gather data without any interventions or treatments.

Why it matters

Potential benefit: If successful, this study could enhance knowledge about the health risks firefighters face due to toxic exposure, potentially leading to improved safety protocols.

How similar studies have gone: While this study focuses on a specific population, similar observational studies have shown success in understanding exposure risks in occupational settings.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Firefighter (career or volunteer)
* Over 18 years of age
* Able to provide written voluntary consent

Exclusion Criteria:

* Unwilling to provide a pre and post-exposure urine sample
* Current cancer diagnosis
* Tobacco use within the last 1 year (verified by urinary TNEs)

Where it's running

  • Masonic Cancer Center
    Minneapolis, Minnesota, United States
    Recruiting

Study contacts

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How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.