Examining endothelial function in patients undergoing non-cardiac surgery
Endothelial Dysfunction During Non-cardiac Surgery and Major Clinical Events
This study is testing how the health of blood vessels affects heart problems in people over 45 who are having non-cardiac surgery.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 200 (estimated) |
| Ages | 45 Years and up |
| Sex | All |
| Sponsor | University of Chile Academic / other |
| Drugs / interventions | chemotherapy |
| Locations | 1 site (Independencia, Santiago Metropolitan) |
| Trial ID | NCT05778981 on ClinicalTrials.gov |
What this trial studies
This observational study investigates the relationship between endothelial dysfunction and cardiovascular events in patients scheduled for non-cardiac surgery. Researchers will evaluate flow-mediated dilatation of the brachial artery and measure troponin levels before, during, and after surgery. A total of 200 patients aged 45 and older will be enrolled, and their clinical outcomes will be monitored at one, three, and six months post-surgery. The study aims to enhance understanding of how endothelial function impacts surgical outcomes and cardiovascular health.
Who should consider this trial
Good fit: Ideal candidates are patients aged 45 years or older scheduled for non-cardiac surgery.
Not a fit: Patients with recent myocardial injury or those expected to have less than two days of hospitalization may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved risk assessment and management strategies for patients undergoing non-cardiac surgery.
How similar studies have performed: Previous studies have indicated a correlation between endothelial function and cardiovascular events, suggesting that this approach may yield valuable insights.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Signed informed consent * Patients 45 years or older Exclusion Criteria: * Refuse to participate in the study * Myocardial injury or acute myocardial infarction less than two weeks ago * Patients who expect less than 2 days of hospitalization * Patients in whom the troponin elevation is attributed to a secondary cause (for example, sepsis, pulmonary thromboembolism, electrical cardioversion, etc.) * Use of chemotherapy less than 2 weeks ago
Where this trial is running
Independencia, Santiago Metropolitan
- Hospital Clínico de la Universidad de Chile — Independencia, Santiago Metropolitan, Chile (Recruiting)
Study contacts
- Study coordinator: Felipe Maldonado, M.D., M.Sc.
- Email: fmaldonado@uchile.cl
- Phone: +56 2 2978 8221
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.