Evaluating the effectiveness of rimegepant for preventing migraines

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This multicentric observational study aims to assess the effectiveness and tolerability of rimegepant, a CGRP receptor antagonist, as a preventive treatment for patients suffering from episodic or chronic migraines. Participants will take a 75 mg orally disintegrating tablet of rimegepant every other day for two years, with data collected at baseline and every three months. The study will also involve maintaining a headache diary to track migraine frequency and severity. The goal is to gather real-world evidence on the drug's performance in preventing migraines.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Diagnosis of migraine without aura or migraine with aura, according to the 3rd edition of the International Classification of Headache Disorder (ICHD-III);
* At least 4 monthly migraine days;
* Good compliance to study procedures;
* Availability of headache diary at least of the preceding months before enrollment.

Exclusion Criteria:

* Subjects with contraindications for use of gepants;
* Diagnosis of chronic migraine
* Concomitant diagnosis of medical diseases and/or comorbidities that, in the Investigator's opinion might interfere with study assessments;
* medical comorbidities that could interfere with study results;
* Pregnancy and breastfeeding.
* Changes in preventive treatments in the month before the first administration of rimegepant

Where it's running

• SOD Centro Cefalee e Farmacologia Clinica, AOU Careggi
  Florence, Florence, Italy Recruiting
• IRCCS National Neurological Institute "C. Mondino" Foundation
  Pavia, Pavia, Italy Recruiting

Study contacts

• Study coordinator: Luigi F Iannone, MD
• Email: luigifrancesco.iannone@unimore.it
• Phone: +393896969606

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Gepants for Acute Migraine in the Emergency Department

  This study tests whether rimegepant or zavegepant given in the ED can relieve an acute migraine for adults.

  Recruiting Phase 1 University of South Florida · Tampa, Florida · NCT07667621

• Analyzing CGRP Levels in Migraine Patients by Age and Sex

  This study looks at the levels of a substance linked to migraines in people with migraines and healthy individuals to see how age and sex might affect treatment responses.

  Recruiting Hospital Universitari Vall d'Hebron Research Institute · Barcelona, Barcelona · NCT06674772

• Evaluating the effectiveness of rimegepant for treating migraines

  This study tests if a new migraine pill called rimegepant can help people with migraines feel better during their attacks and how well they can handle any side effects.

  Recruiting at 2 sites University of Florence · Florence and 1 other locations · NCT05903027

• Comparing telehealth cognitive behavioral therapy for youth with migraines

  This study is testing whether online therapy for kids and teens with migraines works better when combined with medication or on its own.

  Recruiting at 15 sites Children's Hospital Medical Center, Cincinnati · Birmingham, Alabama and 14 other locations · NCT05889624

• Evaluating migraine treatment effects using different designs

  This study is testing how different ways of giving treatment information affect the effectiveness of a migraine medication compared to a placebo in people with episodic migraines.

  Recruiting University of Aarhus · Aarhus C and 1 other locations · NCT06617832

• Remote electrical neuromodulation to test pain inhibition in migraine and fibromyalgia

  We’re testing if the Nerivio wearable can boost the body’s natural pain-inhibition system (CPM) and reduce pain more than a sham device in adults with migraine or fibromyalgia.

  Recruiting Theranica · Bridgewater, New Jersey and 1 other locations · NCT07841509

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.