Evaluating T-cell response in patients with chronic kidney disease

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to assess the immune response in patients suffering from chronic kidney disease, particularly focusing on those with end-stage kidney disease (ESKD). It seeks to define the immunodeficiency characteristics of T cells in these patients and provide an in-vitro proof-of-concept for T-cell engineering. By analyzing blood samples, the study will explore the relationship between T-cell function and the increased risk of infections in ESKD patients, which is a significant cause of mortality in this population.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Male or female ≥ 18 years
2. Informed participants who did not object to participating in the study

Exclusion Criteria:

1. Chronic progressive infections
2. Prior organ transplantation (including bone marrow transplantation)
3. Previous treatment with immunosuppressive agents (such as Rituximab, Eculizumab, Tacrolimus or Ciclosporin, Cellcept or Imurel) within 2 years prior to inclusion
4. Participant under guardianship, curatorship or deprived of liberty
5. Pregnant or breastfeeding women

Where it's running

• Center Hospitalier Universitaire d'Orléans
  Orléans, France Recruiting

Study contacts

• Study coordinator: Manon DEKEYSER, PhD
• Email: manon.dekeyser@chu-orleans.fr
• Phone: +33238229870

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Screening for chronic kidney disease

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.