Evaluating Heart Function During Breathing Trials in ICU Patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial aims to assess cardiac function in ICU patients undergoing spontaneous breathing trials by measuring a specific cardiac ultrasound index (E/E'). The study will compare three different spontaneous breathing trials to determine which one places the least strain on the heart. Participants will simply breathe without respiratory support during these trials, while investigators will conduct cardiac ultrasound measurements to gather data. The goal is to identify the most effective method for weaning patients off mechanical ventilation.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Intubated patient undergoing invasive mechanical ventilation for at least 24 hours and scheduled for a spontaneous breathing trial
* Richmond Agitation Sedation Scale (RASS) between -1 and +1
* Patient at high risk of re-intubation with at least one of the following criteria:

  * Underlying cardiac disease (left ventricular dysfunction with left ventricular ejection fraction ≤ 45%, documented ischemic heart disease, chronic atrial fibrillation, known history of cardiogenic pulmonary edema)
  * Underlying respiratory disease (COPD, Emphysema, bronchial dilatation, asthma, obesity/hypoventilation syndrome, restrictive lung disease)

Exclusion Criteria:

* Neuromuscular pathology (myasthenia type) preceding hospitalization
* Pregnant or breast-feeding women
* Patient already included in the study
* Protected person (under guardianship or curatorship)
* Person under court protection
* Person not affiliated to a social security scheme

Where it's running

• Chu Orleans
  Orléans, France Recruiting

Study contacts

• Study coordinator: Guillaume Fossat, Pt, Msc, PhD student
• Email: guillaume.fossat@chu-orleans.fr
• Phone: +33238651318

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.