Endotracheal suctioning during positive-pressure extubation in the ICU
Removal of the Intubation Tube Under Positive Pressure With or Without Endotracheal Suctioning During Extubation in Intensive Care: a Prospective Randomised Controlled Trial
This tests whether doing endotracheal suctioning during positive-pressure extubation helps adults on mechanical ventilation have better oxygenation (ROX) three hours after extubation.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 120 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Centre Hospitalier Régional d'Orléans Academic / other |
| Locations | 1 site (Orléans, Loiret) |
| Trial ID | NCT07130123 on ClinicalTrials.gov |
What this trial studies
This is a prospective, randomized, controlled trial comparing endotracheal suctioning versus no suctioning during positive-pressure extubation in mechanically ventilated adults. Eligible patients intubated for more than 48 hours and cleared for extubation by their physician are randomized at the time of planned extubation. Respiratory rate, pulse oximetry, and inspired oxygen fraction are recorded for three hours after extubation to calculate the ROX index as the primary short-term outcome. Vital status is recorded up to 28 days after extubation.
Who should consider this trial
Good fit: Adults (over 18) who have been intubated more than 48 hours in the ICU and are prescribed planned extubation by their physician are the intended participants.
Not a fit: Patients with head-of-bed restriction >30°, those with decisions to limit active treatment, pregnant or breastfeeding women, individuals under legal protection, or those without social security affiliation are excluded and therefore will not be eligible to benefit.
Why it matters
Potential benefit: If successful, the intervention could improve short-term oxygenation after extubation and potentially reduce early respiratory compromise.
How similar studies have performed: Similar suctioning techniques are used in clinical practice but randomized evidence on their effect on post-extubation oxygenation is limited.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adult patient * Intubated for more than 48 hours * Patient for whom extubation is prescribed by the patient's physician Exclusion Criteria: * Headboard restriction\>30°. * Decision to limit active treatment in advance of reintubation * Protected person (under guardianship or curatorship) * Person under court protection * Persons deprived of liberty * Persons not affiliated to a social security scheme * Pregnant or breast-feeding woman * No co-inclusion with a study whose period of interest is follow-up within 3 hours of extubation.
Where this trial is running
Orléans, Loiret
- Centre Hospitalier Universitaire d'Orléans — Orléans, Loiret, France (Recruiting)
Study contacts
- Principal investigator: Cécile FOSSAT — Centre Hospitalier Universitaire d'Orléans
- Study coordinator: Cécile FOSSAT
- Email: fanny.louat@chu-orleans.fr
- Phone: +33238575252
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.