Evaluating echocardiography's usefulness in patients with Staphylococcus aureus bacteremia
Evaluation of the Usefulness of Echocardiography in Patients With Staphylococcus Aureus Bacteremia at Low Risk of Infective Endocarditis (ET-AUREUS Study).
This study is testing whether patients with Staphylococcus aureus bacteremia who are considered low-risk really need heart scans to check for infections in the heart.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 470 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Puerta de Hierro University Hospital Academic / other |
| Locations | 1 site (Majadahonda, Madrid) |
| Trial ID | NCT05862025 on ClinicalTrials.gov |
What this trial studies
This prospective cohort study aims to assess the prevalence of infective endocarditis (IE) in patients with Staphylococcus aureus bacteremia who are identified as low-risk using the VIRSTA score. The study will determine if transthoracic or transesophageal echocardiography can be safely omitted in these patients. Additionally, it will evaluate the cost-benefit of avoiding echocardiographic testing for those deemed low-risk. Participants will undergo mandatory echocardiography within the first two weeks of bacteremia onset.
Who should consider this trial
Good fit: Ideal candidates for this study are adults diagnosed with Staphylococcus aureus bacteremia who are considered low-risk for infective endocarditis.
Not a fit: Patients with a history of Staphylococcus aureus bacteremia, those under 18 years old, or individuals with contraindications for echocardiography will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could reduce unnecessary echocardiographic procedures in low-risk patients, leading to cost savings and more efficient patient care.
How similar studies have performed: Other studies have explored the risk of infective endocarditis in similar patient populations, but this specific approach to omitting echocardiography in low-risk cases is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients with Staphylococcus aureus bacteremia Exclusion Criteria: * Previous episode of Staphylococcus aureus bacteremia. * Pregnant women * Patients younger than 18 years old. * High estimated probability of death during 72 hours of study inclusion. * Patients with contraindication of transesophageal echocardiography, including: esophageal varices, other serious esophageal diseases (including tumors, perforation, diverticulum and previous esophageal surgery), severe coagulopathy (platelets count lower than 50.000 cel/mL or I.N.R above 4), low consciousness, recent upper gastroesophageal bleeding, serious espinal vertebrae pathology (previous radiotherapy, active spondylodiscitis, severe spondylarthrosis) * Abscense of written informed consent or patient's negative to undergo echocardiography evaluation.
Where this trial is running
Majadahonda, Madrid
- University Hospital Puerta de Hierro — Majadahonda, Madrid, Spain (Recruiting)
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.