Evaluating DNA Methylation for Diagnosing Thyroid Nodules
Evaluation of DNA Methylation Signatures in Diagnosis and Management of Thyroid Nodules
This study is testing a new DNA test to see if it can help doctors tell the difference between cancerous and non-cancerous thyroid nodules to reduce unnecessary surgeries.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 1450 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | City of Hope Medical Center Academic / other |
| Locations | 1 site (Duarte, California) |
| Trial ID | NCT05229341 on ClinicalTrials.gov |
What this trial studies
This clinical trial assesses the use of DNA methylation signatures to improve the diagnosis and management of thyroid nodules. It aims to develop a new diagnostic test that can differentiate between malignant and benign thyroid tumors using tissue samples obtained through needle biopsies. The study will analyze the effectiveness of this new test compared to existing diagnostic methods, focusing on its predictive values and accuracy in clinical decision-making. By evaluating 800 indeterminate thyroid nodules, the trial seeks to reduce unnecessary surgeries for patients with benign conditions.
Who should consider this trial
Good fit: Ideal candidates are adults over 18 years old who are undergoing needle biopsies for thyroid nodule diagnosis.
Not a fit: Patients under 18 years old or those with impaired decision-making capacity will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to a more accurate diagnostic test for thyroid cancer, reducing unnecessary surgeries for patients.
How similar studies have performed: Other studies have shown promise in using genetic and molecular signatures for cancer diagnosis, indicating potential success for this novel approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients without impaired decision-making capacity and who are undergoing needle biopsies for thyroid nodule diagnosis * Over the age of 18 * Any gender, race and ethnicity * Patients must provide informed consent prior to use of their tissues and clinical data Exclusion Criteria: * Children are excluded from the study, since the biology of children thyroid nodules is different from adults
Where this trial is running
Duarte, California
- City of Hope Medical Center — Duarte, California, United States (Recruiting)
Study contacts
- Principal investigator: John H Yim — City of Hope Medical Center
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.