Evaluating DNA Methylation for Diagnosing Thyroid Nodules
Official title: Evaluation of DNA Methylation Signatures in Diagnosis and Management of Thyroid Nodules
Run by City of Hope Medical Center · NCT05229341 · Data updated 2026-11-12
This study is testing a new DNA test to see if it can help doctors tell the difference between cancerous and non-cancerous thyroid nodules to reduce unnecessary surgeries.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 1450 (estimated) |
| Sponsor | City of Hope Medical Center Academic / other |
| Locations | 1 site (Duarte, California) |
| Status | Recruiting |
| Started | December 23, 2021 |
| Main results expected | January 21, 2027 |
| Study ends | January 21, 2027 |
| Registry record updated | November 5, 2026 |
| Trial ID | NCT05229341 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults over 18 years old who are undergoing needle biopsies for thyroid nodule diagnosis.
✕Probably not a fit
Patients under 18 years old or those with impaired decision-making capacity will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This clinical trial assesses the use of DNA methylation signatures to improve the diagnosis and management of thyroid nodules. It aims to develop a new diagnostic test that can differentiate between malignant and benign thyroid tumors using tissue samples obtained through needle biopsies. The study will analyze the effectiveness of this new test compared to existing diagnostic methods, focusing on its predictive values and accuracy in clinical decision-making. By evaluating 800 indeterminate thyroid nodules, the trial seeks to reduce unnecessary surgeries for patients with benign conditions.
Why it matters
Potential benefit: If successful, this study could lead to a more accurate diagnostic test for thyroid cancer, reducing unnecessary surgeries for patients.
How similar studies have gone: Other studies have shown promise in using genetic and molecular signatures for cancer diagnosis, indicating potential success for this novel approach.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients without impaired decision-making capacity and who are undergoing needle biopsies for thyroid nodule diagnosis * Over the age of 18 * Any gender, race and ethnicity * Patients must provide informed consent prior to use of their tissues and clinical data Exclusion Criteria: * Children are excluded from the study, since the biology of children thyroid nodules is different from adults
Where it's running
-
City of Hope Medical Center
Duarte, California, United States Recruiting
Study contacts
- Principal investigator: John H Yim — City of Hope Medical Center
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Identifying and differentiating thyroid nodules using acoustic imaging
This study is testing new imaging techniques to see if they can better identify and tell apart thyroid nodules, helping patients understand if their nodules are cancerous or not.
-
Developing blood tests for diagnosing thyroid cancer
This study is testing a new blood test to help doctors tell if thyroid nodules are cancerous or not, using samples from patients with suspicious nodules or thyroid cancer.
-
Investigational imaging for monitoring treatment response in thyroid cancer and head and neck malignancies
This study is testing if a special type of MRI can help doctors see how well treatment is working for people with thyroid cancer and head and neck cancers.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.