Identifying and differentiating thyroid nodules using acoustic imaging
Identification and Differentiation of Thyroid Nodules by Acoustic Imaging and Viscoelastic Parameters
Mayo Clinic · NCT06207188
This study is testing new imaging techniques to see if they can better identify and tell apart thyroid nodules, helping patients understand if their nodules are cancerous or not.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 650 (estimated) |
| Ages | 8 Years and up |
| Sex | All |
| Sponsor | Mayo Clinic (other) |
| Locations | 3 sites (Scottsdale, Arizona and 2 other locations) |
| Trial ID | NCT06207188 on ClinicalTrials.gov |
What this trial studies
This observational study aims to identify and differentiate thyroid nodules through advanced acoustic imaging techniques and viscoelastic parameters. It will evaluate the effectiveness of vibro-acoustography in detecting thyroid nodules and compare its specificity in distinguishing between malignant and benign nodules against traditional ultrasound methods. Additionally, the study will assess the diagnostic value of Shear Wave Ultrasound Vibrometry and Comb Push shear elastography in correlating results with pathology. The study will also explore the response to alcohol ablation in patients with recurrent thyroid cancer.
Who should consider this trial
Good fit: Ideal candidates include male and female patients aged 8 and older who are suspected of having thyroid cancer or have palpable lymph nodes requiring biopsy.
Not a fit: Patients under 8 years old or those who have recently undergone biopsy procedures for thyroid nodules or lymph nodes may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to more accurate and non-invasive methods for diagnosing thyroid cancer, improving patient outcomes.
How similar studies have performed: Other studies have shown promise in using acoustic imaging techniques for similar diagnostic purposes, indicating potential for success in this approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * \* Male and female patient volunteers ages 8 and up who are suspicious for thyroid cancer * Patients who have palpable and sonographically detectable lymph nodes or nonthyroidal neck masses and are referred to Radiology Department or Endocrinology for fine-needle aspiration biopsy (FNAB) * Patients 18 and up who were previously diagnosed with thyroid cancer and treated with thyroidectomy and recently diagnosed as having recurrence nodes on thyroid bed or on their neck Exclusion Criteria: * Because thyroid cancer is rare under the age of 8 years, children younger than this age are excluded from the study * Having FNAB or surgical biopsy on thyroid in less than two weeks for thyroid nodule detection group * Having FNAB or surgical biopsy on cervical lymph nodes or non- thyroidal masses for this group of patients
Where this trial is running
Scottsdale, Arizona and 2 other locations
- Mayo Clinic in Arizona — Scottsdale, Arizona, United States (RECRUITING)
- Mayo Clinic in Florida — Jacksonville, Florida, United States (RECRUITING)
- Mayo Clinic in Rochester — Rochester, Minnesota, United States (RECRUITING)
Study contacts
- Principal investigator: Azra Alizad, MD — Mayo Clinic in Rochester
- Study coordinator: Clinical Trials Referral Office
- Email: mayocliniccancerstudies@mayo.edu
- Phone: 855-776-0015
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Thyroid Gland Carcinoma