Investigational imaging for monitoring treatment response in thyroid cancer and head and neck malignancies
Pilot Study of Metabolic Guidance for Therapy in Patients With Thyroid Cancer and Other Malignancies of the Head and Neck
This study is testing if a special type of MRI can help doctors see how well treatment is working for people with thyroid cancer and head and neck cancers.
Quick facts
| Phase | Phase 1 |
|---|---|
| Study type | Interventional |
| Enrollment | 42 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | M.D. Anderson Cancer Center Academic / other |
| Drugs / interventions | radiation |
| Locations | 1 site (Houston, Texas) |
| Trial ID | NCT04589624 on ClinicalTrials.gov |
What this trial studies
This trial evaluates the use of hyperpolarized magnetic resonance imaging (hpMRI) to predict treatment responses in patients with thyroid cancer and other head and neck malignancies undergoing radiation and/or systemic therapy. Participants will receive hpMRI scans at baseline and one week after treatment initiation, allowing researchers to assess early metabolic changes. The study aims to gather pilot data on the effectiveness of hpMRI in guiding treatment decisions for these patients.
Who should consider this trial
Good fit: Ideal candidates include patients diagnosed with thyroid cancer or other head and neck malignancies who are preparing for treatment.
Not a fit: Patients with severe claustrophobia, certain medical implants, or those who are pregnant or breastfeeding may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could enhance treatment planning and improve outcomes for patients with thyroid cancer and head and neck malignancies.
How similar studies have performed: While the use of hpMRI is a novel approach, similar imaging techniques have shown promise in other malignancies, suggesting potential for success.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Be willing and able to provide informed consent * Be informed of the investigational nature of this study * Be diagnosed with thyroid cancer and other malignancies of the head and neck with intent for treatment Exclusion Criteria: * Have a history of severe claustrophobia * Have electrically, magnetically or mechanically activated implants that would preclude magnetic resonance imaging (MRI) * Have a history of cardiac arrhythmia * Have an allergy to Gadavist intravenous contrast * Estimated glomerular filtration rate (eGFR) \< 30 * If female, be pregnant or breast feeding at time of consent
Where this trial is running
Houston, Texas
- M D Anderson Cancer Center — Houston, Texas, United States (Recruiting)
Study contacts
- Principal investigator: Stephen Y Lai — M.D. Anderson Cancer Center
- Study coordinator: Stephen Y Lai
- Email: sylai@mdanderson.org
- Phone: 713-792-6528
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.