Evaluating coronary microvascular dysfunction in heart failure patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study investigates the incidence of coronary microvascular dysfunction (CMD) and its prognostic implications for improving left ventricular function in patients diagnosed with heart failure with reduced ejection fraction (HFrEF) due to non-ischemic causes. The study will utilize invasive physiological assessments to evaluate CMD, specifically measuring coronary flow reserve (CFR) and the index of microcirculatory resistance (IMR). By understanding the relationship between CMD and left ventricular function improvement after guideline-directed medical treatment, the study aims to provide insights into the management of HFrEF patients. The findings could help identify patients at risk for irreversible myocardial damage.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* a) Subject must be at least 19 years of age. b) Subject with symptoms or signs of HF (NYHA ≥2 dyspnea) and reduced ejection fraction (LVEF ≤ 40%) c) Subject who clinically need coronary angiography d) Subject who can voluntarily sign informed consent form

Exclusion Criteria:

* a) Subject with significant coronary artery stenosis on coronary angiography (diameter stenosis ≥90% or 50-90% with fractional flow reserve \[FFR\] ≤0.80) b) Subject scheduled for cardiac replacement therapy (heart transplantation or left ventricular assisted device \[LVAD\] implantation) c) HF due to restrictive cardiomyopathy, active myocarditis, or constrictive pericarditis d) Significant valvular heart disease requiring surgery e) Subject who have non-cardiac co-morbid conditions with life expectancy \<1 year

Where it's running

• Samsung Medical Center
  Seoul, South Korea Recruiting

Study contacts

• Principal investigator: Ki Hong Choi, MD — Samsung Medical Center
• Study coordinator: Ki Hong Choi, MD
• Email: cardiokh@gmail.com
• Phone: 82-2-3410-3419

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.