Evaluating brain MRI features in patients with CASPR2 limbic encephalitis
Brain MRI Longitudinal Volumetric Characteristics Associated With Outcomes of CASPR2-Limbic Encephalitis
This study looks at brain MRI scans from patients with CASPR2 limbic encephalitis to see how these images relate to their symptoms and overall health.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 27 (estimated) |
| Ages | 18 Years to 100 Years |
| Sex | All |
| Sponsor | Hospices Civils de Lyon Academic / other |
| Locations | 1 site (Bron) |
| Trial ID | NCT06245447 on ClinicalTrials.gov |
What this trial studies
This observational study focuses on patients diagnosed with autoimmune encephalitis associated with anti-CASPR2 antibodies. It aims to conduct a retrospective evaluation of brain MRI characteristics to understand their relationship with clinical outcomes. The study will analyze MRI records from patients who have tested positive for CASPR2 antibodies in their cerebrospinal fluid. By examining these MRI features, the research seeks to provide insights into the progression and manifestations of this rare neurological disorder.
Who should consider this trial
Good fit: Ideal candidates include individuals over 50 years old with a confirmed diagnosis of CASPR2-antibody-associated encephalitis and available MRI records.
Not a fit: Patients with other antibody positivity against neural or glial antigens or those without sufficient clinical data may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance understanding of CASPR2 limbic encephalitis and improve diagnostic and treatment strategies for affected patients.
How similar studies have performed: While there is limited data on similar studies, the approach of evaluating MRI characteristics in autoimmune encephalitis is promising and may yield valuable insights.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients with a definite diagnosis of CASPR2-antibody-associated encephalitis * available MRI records * Ascertained positivity for CASPR2-antibodies in CSF Exclusion Criteria: * Positivity for another antibody against neural or glial antigens * MRI images not available * Not enough clinical data to ascertain outcome
Where this trial is running
Bron
- Hospices Civils de Lyon — Bron, France (Recruiting)
Study contacts
- Study coordinator: Bastien Joubert, professor
- Email: Bastien.joubert@chu-lyon.fr
- Phone: +334 78 86 15 53
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.