Evaluating blood vessel function in patients with resistant hypertension
Evaluation of Systemic Microvascular Reactivity in Patients With Resistant Hypertension
This study is testing how well the tiny blood vessels work in people with high blood pressure that doesn't respond to regular treatments to better understand their condition and related heart risks.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 150 (estimated) |
| Ages | 18 Years to 75 Years |
| Sex | All |
| Sponsor | National Institute of Cardiology, Laranjeiras, Brazil Government |
| Locations | 1 site (Rio de Janeiro) |
| Trial ID | NCT05464849 on ClinicalTrials.gov |
What this trial studies
This observational study focuses on patients with resistant arterial hypertension, characterized by high blood pressure that remains uncontrolled despite treatment with multiple antihypertensive medications. The research aims to assess the microvascular reactivity by examining cutaneous capillary density and the endothelial function using advanced imaging techniques. By understanding the role of microcirculation in resistant hypertension, the study seeks to provide insights into the underlying mechanisms of this condition and its cardiovascular risks.
Who should consider this trial
Good fit: Ideal candidates for this study are individuals diagnosed with resistant hypertension who are currently on multiple antihypertensive medications.
Not a fit: Patients with non-resistant hypertension or those with endocrine diseases, autoimmune diseases, or cancer may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved understanding and management of resistant hypertension, potentially reducing cardiovascular risks for patients.
How similar studies have performed: While the specific approach of this study may be novel, previous studies have indicated the importance of microvascular function in hypertension, suggesting potential for meaningful insights.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Resistant hypertension Exclusion Criteria: * Pregnancy or lactation for all groups. * For the control group: endocrine and metabolic diseases, including diabetes mellitus, cardiovascular diseases, including hypertension, autoimmune diseases and cancer. * For the resistant arterial hypertension and non-resistant arterial hypertension groups: endocrine diseases, except diabetes mellitus, autoimmune diseases and cancer .
Where this trial is running
Rio de Janeiro
- Eduardo Tibiriçá — Rio de Janeiro, Brazil (Recruiting)
Study contacts
- Study coordinator: Eduardo Tibirica
- Email: etibi@uol.com.br
- Phone: +55-21-99914-6075
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.