Evaluating blood renin levels during heart surgery
Evaluation of Plasma Renin Concentrations in Cardiac Surgery
Mayo Clinic · NCT06895213
This study looks at how heart surgery affects renin levels in the blood to see if changes could help explain low blood pressure after the surgery.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 100 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Mayo Clinic (other) |
| Locations | 1 site (Rochester, Minnesota) |
| Trial ID | NCT06895213 on ClinicalTrials.gov |
What this trial studies
This observational study aims to investigate how plasma renin concentrations are affected by cardiopulmonary bypass during cardiac surgery. Researchers will collect blood samples to measure renin levels at various points throughout the surgical procedure. The study hypothesizes that exposure to cardiopulmonary bypass will lead to increased renin concentrations, which may correlate with the development of vasoplegia, a condition characterized by low blood pressure. The findings could provide insights into the prognostic value of renin levels for patient outcomes post-surgery.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18 and older scheduled for elective cardiac surgery involving cardiopulmonary bypass.
Not a fit: Patients undergoing emergency cardiac surgery or those with congenital heart disease or end-stage kidney disease may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could help identify patients at risk for low blood pressure during surgery and guide treatment strategies.
How similar studies have performed: While the specific approach of evaluating renin levels during cardiopulmonary bypass is novel, studies on the renin-angiotensin system in cardiac surgery have shown promising insights.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adult persons 18 years of age or greater. * Scheduled for an elective cardiac surgical procedure involving the use of cardiopulmonary bypass. Exclusion Criteria: * Surgery involving heart or lung transplantation or implant of a durable left ventricular assist device. * Emergency cardiac surgery. * Established diagnosis of any congenital heart disease. * End-stage kidney disease receiving kidney replacement therapy before surgery.
Where this trial is running
Rochester, Minnesota
- Mayo Clinic — Rochester, Minnesota, United States (RECRUITING)
Study contacts
- Principal investigator: Patrick M Wieruszewski, Pharm.D. — Mayo Clinic
- Study coordinator: Patrick M Wieruszewski, Pharm.D.
- Email: wieruszewski.patrick@mayo.edu
- Phone: 507-255-5732
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Cardiac Surgery With Cardiopulmonary Bypass, renin-angiotensin system, RAS, hypotension, perfusion, shock, blood pressure