Evaluating blood flow in hand arteries using advanced MRI techniques
Official title: Qualitative and Quantitative Evaluation of Vascular Flows of Radial, Ulnar and Interdigital Arterial Trees Under Normal and Pathological Conditions by 3 Tesla MRI
Run by Centre Hospitalier Universitaire, Amiens · NCT04257747 · Data updated 2026-11-12
This study is testing a new MRI method to see how blood flows in the hands of healthy people and those who have had specific surgeries, to help improve care for hand transplants.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 46 (estimated) |
| Sponsor | Centre Hospitalier Universitaire, Amiens Academic / other |
| Locations | 1 site (Amiens) |
| Status | Recruiting |
| Started | September 1, 2021 |
| Main results expected | May 2028 |
| Study ends | March 2029 |
| Registry record updated | June 10, 2025 |
| Trial ID | NCT04257747 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include adults who are healthy volunteers or patients requiring radial forearm flap reconstruction or who have received hand allotransplantation.
✕Probably not a fit
Patients with contraindications to MRI or those with upper limb arteriopathy (excluding hand transplant patients) may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study aims to assess the vascular flows of the radial, ulnar, and interdigital arterial trees in both healthy individuals and patients with specific conditions such as radial forearm flap reconstruction and hand allotransplantation. Utilizing a specialized flow MRI protocol developed by the research team, the study will quantitatively analyze blood flow patterns to improve monitoring of vascularized composite tissue transplants. The research involves MRI acquisitions and Doppler ultrasound procedures to gather comprehensive data on arterial health and function.
Why it matters
Potential benefit: If successful, this study could enhance the monitoring and management of vascular complications in hand transplants, potentially reducing graft loss.
How similar studies have gone: While flow MRI has been previously applied in facial allotransplantation, this specific application to hand arterial trees is novel and has not been extensively tested.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adult (≥ 18 years old) * patients who has received appropriate information and provided informed consent * patients benefiting from social security insurance * patients with no contraindications to magnetic resonance imaging * healthy volunteer or patient requiring radial forearm flap reconstruction or having received hand allotransplantation. Exclusion Criteria: * Person with a contraindication to MRI * pregnant or breastfeeding woman * minors (\< 18 years) * person under guardianship or deprived of liberty by a judicial or administrative decision * person with upper limb arteriopathy with the exception of the hand transplant patients group.
Where it's running
-
CHU Amiens
Amiens, France Recruiting
Study contacts
- Principal investigator: Stéphanie Dakpe, MD — CHU Amiens
- Study coordinator: Sylvie testelin, Pr
- Email: testelin.sylvie@chu-amiens.fr
- Phone: (33)322089070
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.