Evaluating blood flow in hand arteries using advanced MRI techniques
Qualitative and Quantitative Evaluation of Vascular Flows of Radial, Ulnar and Interdigital Arterial Trees Under Normal and Pathological Conditions by 3 Tesla MRI
This study is testing a new MRI method to see how blood flows in the hands of healthy people and those who have had specific surgeries, to help improve care for hand transplants.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 46 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Centre Hospitalier Universitaire, Amiens Academic / other |
| Locations | 1 site (Amiens) |
| Trial ID | NCT04257747 on ClinicalTrials.gov |
What this trial studies
This study aims to assess the vascular flows of the radial, ulnar, and interdigital arterial trees in both healthy individuals and patients with specific conditions such as radial forearm flap reconstruction and hand allotransplantation. Utilizing a specialized flow MRI protocol developed by the research team, the study will quantitatively analyze blood flow patterns to improve monitoring of vascularized composite tissue transplants. The research involves MRI acquisitions and Doppler ultrasound procedures to gather comprehensive data on arterial health and function.
Who should consider this trial
Good fit: Ideal candidates include adults who are healthy volunteers or patients requiring radial forearm flap reconstruction or who have received hand allotransplantation.
Not a fit: Patients with contraindications to MRI or those with upper limb arteriopathy (excluding hand transplant patients) may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance the monitoring and management of vascular complications in hand transplants, potentially reducing graft loss.
How similar studies have performed: While flow MRI has been previously applied in facial allotransplantation, this specific application to hand arterial trees is novel and has not been extensively tested.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adult (≥ 18 years old) * patients who has received appropriate information and provided informed consent * patients benefiting from social security insurance * patients with no contraindications to magnetic resonance imaging * healthy volunteer or patient requiring radial forearm flap reconstruction or having received hand allotransplantation. Exclusion Criteria: * Person with a contraindication to MRI * pregnant or breastfeeding woman * minors (\< 18 years) * person under guardianship or deprived of liberty by a judicial or administrative decision * person with upper limb arteriopathy with the exception of the hand transplant patients group.
Where this trial is running
Amiens
- CHU Amiens — Amiens, France (Recruiting)
Study contacts
- Principal investigator: Stéphanie Dakpe, MD — CHU Amiens
- Study coordinator: Sylvie testelin, Pr
- Email: testelin.sylvie@chu-amiens.fr
- Phone: (33)322089070
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.