How preoperative QFR might affect graft outcomes after CABG

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is an observational study evaluating the potential impact of preoperative Quantitative Flow Reserve (QFR) assessment on early graft performance after CABG. Researchers will follow adults aged 18 to 80 who are scheduled for CABG and have preoperative QFR data, tracking graft patency and major adverse cardiac and cerebrovascular events (MACE) for one year. Data collection will occur through regular follow-up visits and patient-reported health questionnaires. The study is conducted at Peking University Third Hospital, with no stated collaborators, focusing on patients with significant multivessel coronary disease. Results could inform whether preoperative QFR informs surgical planning and postoperative risk.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients aged 18 to 80 years.
* Patients whose angina pectoris significantly affects daily life and work, and for whom conservative medical treatment is ineffective, requiring coronary artery bypass grafting (CABG).
* Preoperative coronary angiography data are available for quantitative flow ratio (QFR) analysis.
* Patients with severe stenosis, defined as greater than 70% stenosis, in the three main coronary artery branches, including the left anterior descending artery, circumflex artery, and right coronary artery, with or without left main coronary artery stenosis greater than 50%.

Exclusion Criteria:

* Patients who cannot tolerate CABG due to comorbidities or complications.
* Patients requiring urgent CABG or percutaneous coronary intervention (PCI).
* Patients with significant congestive heart failure or hemodynamic instability.
* Patients with a history of previous CABG or PCI within the past 6 months.
* Patients who have experienced a stroke within the past 6 months.
* Patients requiring concurrent cardiac procedures, such as valve surgery, maze surgery, radiofrequency ablation, or pacemaker implantation.
* Patients with allergies to contrast agents or antiplatelet medications, or with contraindications to antiplatelet medications due to bleeding risks.
* Patients with a significant history of bleeding, marked leukopenia, neutropenia, thrombocytopenia, anemia, or bleeding diathesis.
* Patients currently participating in other prospective clinical studies.
* Patients who are unwilling to participate in this study.

Where it's running

• Peking university third hospital
  Beijing, Beijing Municipality, China Recruiting

Study contacts

• Study coordinator: Tong Ding, MD
• Email: dt1067723747@gmail.com
• Phone: +8613132150173

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.