Evaluating a new treatment for acute ischemic stroke after reperfusion

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to assess the safety and efficacy of in situ ischemic postconditioning (ISIPC) in patients with acute ischemic stroke (AIS) who have undergone successful reperfusion through endovascular treatment. The approach involves performing five cycles of balloon inflations in the ipsilateral internal carotid artery immediately after reperfusion, with each cycle consisting of 15 seconds of inflation followed by 15 seconds of deflation. The study will include adult patients with specific criteria related to stroke severity and imaging results. It is observational in nature, focusing on the outcomes of this novel intervention.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Adult (age ≥ 18 to 95 years) patients with an occlusion of the internal carotid artery or M1 or M2 segment of the middle cerebral artery,;
2. Patients with a score of at least 6 on the National Institutes of Health Stroke Scale (NIHSS) at admission and a score of 0 or 1 on the modified Rankin scale before the onset of stroke;
3. Patients with a score of at least 6 on the Alberta Stroke Program Early CT score (ASPECTS) value;
4. Baseline multimodal-CT imaging, including NCCT, CTA and CTP, performed at the trial-site hospital
5. The modified thrombolysis in cerebral infarction (mTICI) scale 2b to 3 achieved in the infarct-related artery after the last thrombectomy attempt

Exclusion Criteria:

1. Stoke of large artery atherosclerotic origin or other determined factors (such as dissection) or tandem occlusion;
2. Patients underwent rescue angioplasty or stenting after thrombectomy

Where it's running

• Zhangzhou Municipal Hospital of Fujian Province
  Zhangzhou, Fujian, China Recruiting
• Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
  Shanghai, China Recruiting

Study contacts

• Study coordinator: Yueqi Zhu, PhD
• Email: zhuyueqi@hotmail.com
• Phone: +86-21-18930177565

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.