Evaluating a new red blood cell therapy for advanced cancers

A Multicenter, Single-arm, Open-label, Dose-escalation and Dose-expansion Clinical Study Evaluating the Safety, Tolerability and Preliminary Efficacy of Engineered Red Blood Cell in Patients With Advanced Malignancies

This study is testing a new therapy using specially designed red blood cells to see if it can help people with advanced cancers feel better and improve their treatment options.

Quick facts

• Phase: Early Phase 1
• Study type: Interventional
• Enrollment: 30 (estimated)
• Ages: 18 Years to 75 Years
• Sex: All
• Sponsor: Westlake Therapeutics (Industry-sponsored)
• Drugs / interventions: radiation
• Locations: 1 site (Hangzhou, Zhejiang)
• Trial ID: NCT05707325 on ClinicalTrials.gov

What this trial studies

This trial investigates the safety and preliminary efficacy of a novel therapy using engineered red blood cells that are conjugated with checkpoint inhibitors in patients with advanced malignancies. The study consists of two parts: a dose escalation phase following a '3+3' design to determine the optimal dose, and a subsequent dose expansion phase based on the results of the escalation. Patients with various types of advanced solid tumors and hematologic malignancies will be enrolled to assess the treatment's effectiveness and tolerability.

Who should consider this trial

Good fit: Ideal candidates include adults aged 18 to 75 with advanced solid tumors or relapsed/refractory hematologic malignancies who have received prior therapies.

Not a fit: Patients with early-stage cancers or those who have not yet undergone standard treatment may not benefit from this study.

Why it matters

Potential benefit: If successful, this therapy could provide a new treatment option for patients with advanced cancers who have limited alternatives.

How similar studies have performed: While this approach is innovative, similar studies using engineered cell therapies have shown promise in other contexts, suggesting potential for success.

Eligibility criteria

Inclusion Criteria:

* 1.Histologically- or cytologically-proven advanced malignancies;
* 2.Male or female, 18 years of age or older but no more than 75 at the time of signing informed consent;
* 3.Dose escalation stage: (1) patients with advanced solid tumors who have received at least 2 regimens, and PDx monotherapy or combination therapy is included in the last regimen ; or patients received 1st regimen or above who cannot tolerate standard therapy but PDx monotherapy or combination therapy should be included in the last regimen.(2)Patients with relapsed and refractory malignant lymphomas (including: classic Hodgkin lymphoma (cHL), primary mediastinal large B-cell lymphoma PMBCL , Extranodal NK/T-cell lymphoma ENKTCL, mycosis fungoides/Sezari syndrome MF/SS) , or patients have no standard therapy, or are unable to receive standard therapy, PDx monotherapy or combination therapy is used in the last regimen.(3)All patients did not receive systemic therapy after disease progression and the time of disease progression cannot exceed 3 months, radiotherapy was acceptable (definition of secondary resistance: achieved disease control (including CR/PR/ SD), but then disease progression after PDx therapy);
* 4.Dose expansion stage:(1)patients with advanced solid tumors who have received at least 1 regimen or these is no standard systematic therapy or patients can not recieve standard therapy, but PDx monotherapy or combination therapy should be included in the last regimen.(2)patients with relapsed and refractory malignant lymphomas who have no standard therapy or can not receive standard therapy, but PDx monotherapy or combination therapy should be included in the last regimen.(3)All patients did not receive systemic therapy after disease progression and the time of disease progression cannot exceed 3 months, radiotherapy was acceptable (definition of secondary resistance: achieved disease control (including CR/PR/ SD), but then disease progression after PDx therapy);
* 5.Solid tumor：at least one lesion that is measurable according to RECIST 1.1;lymphomas:at least one visble or evaluable lesion that is measurable according to Lugano2014;
* 6.Eastern Cooperative Oncology Group (ECOG) performance status 0 or 1;
* 7.Take the shorter one as the washout period before experimental treatment (28 days after the last tumor treatment, or 5 half lives);
* 8.Resolution of all acute reversible toxic effects of prior therapy or surgical procedure to baseline or Grade ≤1 (except alopecia and peripheral neurotoxicity);
* 9.Adequate organ function;
* 10.Estimated life expectancy of ≥12 weeks;
* 11.Capable of giving signed informed consent which includes compliance with the requirements and restrictions listed in the informed consent form (ICF).

Exclusion Criteria:

* 1.Any active or recently diagnosed clear or suspected autoimmune disorder disease;
* 2\. Other serious medical diseases, including but not limited to: uncontrolled diabetes, active peptic ulcer, liver cirrhosis, active bleeding, etc., and those with uncontrolled or serious cardiovascular disease, such as the NYHA II or higher heart failure, unstable angina, myocardial infarction and other cardiovascular disease within 6 months before first administration, and uncontrolled hypertension (systolic blood pressure ≥ 180 mmHg and/or diastolic blood pressure ≥ 100 mmHg);
* 3.Has known active Hepatitis B or Hepatitis C or HIV;
* 4.Active brain metastases and/or cancerous meningitis;
* 5.Known history of any diseases affecting the quality and stability of erythropoiesis;
* 6.The spleen has been removed or, as judged by the investigator, a splenectomy may be planned during the trial;
* 7.Received at least one alive virus vaccination within 6 months before the first dose (except for the COVID-19 inactivated vaccine);
* 8.Known history of pulmonary fibrosis, interstitial pneumonia, pneumoconiosis, radiation pneumonia, drug-related pneumonia, severely impaired lung function, etc.

Where this trial is running

Hangzhou, Zhejiang

• Zhejiang Provincial People'S Hospital — Hangzhou, Zhejiang, China (Recruiting)

Study contacts

• Principal investigator: xiangmin Tong, Phd — ZHEJIANG PROVINCIAL PEOPLE'S HOSPITAL of China
• Study coordinator: xiangmin Tong, Phd

Conditions Cancer; Solid Tumor; Hematologic Malignancy; solid tumors; hematologic malignancies