Environmental exposure checks in high-risk and early-onset breast cancer care

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study explores attitudes toward environmental exposure risk assessments (EERA) and return of results among female breast cancer patients and their providers. It has three aims: (I) gauge patient interest and emotional responses through surveys and interviews, plus medical record review; (II) assess COH providers' views on integrating EERA into workflows; (III) have patients complete baseline and follow-up surveys, wear a wristband for one week, and undergo occasional interviews with medical record review. Participants are adults 18+ who are English- or Spanish-speaking, with average/high risk or early-onset breast cancer, and who consent to participate. The study is non-interventional and observational in nature.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* AIM 1 INCLUSION CRITERIA:

  * ONE of the following:

    * Either average risk of developing breast cancer (defined by woman with no Tyrer-Cuzick model ≥ 20%, no mention of Tyrer-Cuzick model, and no Pathogenic/Likely Pathogenic \[P/LP\] in breast cancer related genes) OR high risk of developing breast cancer (defined by ≥ 20% chance of developing breast cancer across lifetime measured by Tyrer-Cuzick model or gene mutation carrier, P/LP carrier in breast cancer related genes including BRCA1, BRCA2, BARD1, ATM, CHEK2, CDH1, NF1, PALB2, PTEN, RAD51C, RAD51D, STK11, TP53) OR early onset breast cancer (defined by a breast cancer diagnosis in a patient younger than 50 years of age)
  * Age: ≥ 18 years
  * Speak English or Spanish
  * Sex: female
  * Willingness to:

    * Participate in study activities
    * Permit medical record/ clinical laboratory result review
* AIM 2 INCLUSION CRITERIA

  * Practice at COH (i.e., genetic counselors, geneticists, oncologists, nurse practitioners)
  * Willingness to:

    * Participate in study activities
* AIM 3 INCLUSION CRITERIA:

  * Provide written consent
  * ONE of the following:

    * Either average risk of developing breast cancer (defined by woman with no Tyrer-Cuzick model ≥ 20%, no mention of Tyrer-Cuzick model, and no P/LP in breast cancer related genes) OR High risk: empirical risk of developing breast cancer (defined by ≥ 20% chance of developing breast cancer across lifetime measured by Tyrer-Cuzick model and no P/LP in breast cancer related genes) OR High Risk: gene carrier (defined by P/LP carrier in breast cancer related genes, including BRCA1, BRCA2, BARD1, ATM, CHEK2, CDH1, NF1, PALB2, PTEN, RAD51C, RAD51D, STK11, TP53)
  * Age: ≥ 18 years
  * Speak English or Spanish
  * Sex: female
  * Willingness to:

    * Wear the wristband for 1 week
    * Participate in study activities
    * Permit medical record/ clinical laboratory result review

Where it's running

• City of Hope Medical Center
  Duarte, California, United States Recruiting

Study contacts

• Principal investigator: Stacy W Gray — City of Hope Medical Center

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Mobile health navigation to improve breast cancer screening in Kenyan women

  This study tests m-Health patient navigation tools to help women in Kenya access breast cancer screening and early detection services.

  Recruiting Emory University · Atlanta, Georgia · NCT07764796

• Blended e-Health Program to Help Women with Breast or Gynecologic Cancer Manage Fear of Cancer Progression

  This trial tests a blended online and group program to see if it helps women with breast or gynecologic cancer feel less fear that their cancer could grow or spread.

  Recruiting at 11 sites City of Hope Medical Center · Arcadia, California and 10 other locations · NCT07741968

• CSF sample collection from people with metastatic breast cancer to see brain metastasis risk

  This study tests whether spinal fluid and other samples can help predict brain metastases in adults with metastatic HER2-positive or triple-negative breast cancer who have not yet shown brain involvement.

  Recruiting National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT07619534

• Body composition and outcomes after breast reconstruction

  This study will see if detailed body composition measurements can help predict complications after mastectomy with immediate breast reconstruction in adult women.

  Recruiting University of California, San Francisco · San Francisco, California · NCT07546331

• Support tool for women with HR+ breast cancer on long-term endocrine therapy

  This study tests a SHIELD web- and app-based portal to help women with hormone receptor–positive breast cancer manage symptoms while on long-term endocrine treatment.

  Recruiting Dana-Farber Cancer Institute · Boston, Massachusetts · NCT07482384

• Personalized Exercise Plan for Breast Cancer Survivors on Chemotherapy

  This trial tests whether adding a guided exercise program to a healthy-lifestyle education plan helps breast cancer patients undergoing chemotherapy maintain fitness, heart health, and quality of life.

  Recruiting at 3 sites Wake Forest University Health Sciences · Winston-Salem, North Carolina and 3 other locations · NCT07474090

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.