Endothelial extracellular vesicles as markers of endothelial activation in adults with newly diagnosed high blood pressure

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational, case–control study compares circulating endothelial extracellular vesicles between normotensive adults and adults with untreated, newly diagnosed primary hypertension. Researchers will examine how EEV levels relate to blood pressure measurements, microvascular function measured by laser Doppler flowmetry, and other markers of endothelial activation. The study aims to clarify whether EEVs reflect early endothelial changes in hypertension and could serve as noninvasive biomarkers of vascular risk. No interventions are applied; the focus is on biomarker associations in untreated individuals. Recruitment includes adults 18 and older who meet criteria for normotension or newly diagnosed hypertension without prior treatment.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adults aged 18 years or older.
* Ability and willingness to provide written informed consent.
* Normotensive individuals or individuals with newly diagnosed, previously untreated primary hypertension, classified according to the European Society of Hypertension (ESH) guidelines.
* Ability to comply with all study procedures.

Exclusion Criteria:

* Secondary hypertension.
* Previous treatment with antihypertensive medication.
* History of cardiovascular disease (except newly diagnosed primary hypertension in the hypertensive group).
* Diabetes mellitus.
* Chronic kidney disease.
* Cerebrovascular disease.
* Peripheral arterial disease.
* Acute or chronic inflammatory or infectious disease.
* Active malignancy.
* Pregnancy or breastfeeding.
* Current use of oral contraceptives, hormone replacement therapy, or medications known to affect endothelial function.
* Inability or unwillingness to provide informed consent.

Where it's running

• Faculty of Medicine Osijek
  Osijek, Croatia Recruiting

Study contacts

• Study coordinator: Ana Stupin, MD, PhD
• Email: ana.stupin@mefos.hr
• Phone: +38531512800

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.