Electroacupuncture and Exercise for Chemotherapy-Induced Peripheral Neuropathy
Official title: Electro-Acupuncture Combined With Exercise for Chemotherapy-Induced Peripheral Neuropathy in Patients Receiving Taxanes or Platinum-based Agents: A Randomized Controlled Trial
Run by Show Chwan Memorial Hospital · NCT07700901 · Data updated 2026-11-12
This study tests whether adding a structured exercise program to electroacupuncture helps cancer survivors with CIPN more than electroacupuncture alone.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 80 Years |
| Sex | All |
| Enrollment | 82 (estimated) |
| Sponsor | Show Chwan Memorial Hospital Academic / other |
| Drugs / interventions | chemotherapy |
| Locations | 2 sites (Changhua, Changhua and 1 other locations) |
| Status | Recruiting |
| Started | July 23, 2026 |
| Main results expected | February 28, 2027 |
| Study ends | July 15, 2027 |
| Registry record updated | August 28, 2026 |
| Trial ID | NCT07700901 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults with a confirmed cancer diagnosis who have CIPN symptoms after taxane or platinum chemotherapy, with CTCAE grade 1–3, and the ability to walk independently.
✕Probably not a fit
Patients without CIPN symptoms, those with prohibitive cardiac devices or other exclusion criteria, or those unable to participate in exercise may not benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This interventional study investigates a non-drug approach for chemotherapy-induced peripheral neuropathy by combining electroacupuncture with a progressive exercise program. Participants are randomized to receive either the combination therapy or electroacupuncture alone, with supervised visits and home-based, video-guided practice. The goal is to see if the joint approach provides greater relief from neuropathic symptoms and improves balance and function. The program emphasizes standardized acupuncture stimulation, multimodal exercise, and health education to support adherence and safety. The trial targets adults with a cancer history who have CIPN after taxane or platinum-based chemotherapy.
Why it matters
Potential benefit: If successful, patients could experience reduced neuropathic symptoms and better balance and function without added medications.
How similar studies have gone: Previous non-pharmacologic approaches show promise for CIPN, and combining modalities like acupuncture with exercise is a logical next step, though evidence remains exploratory.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Confirmed cancer diagnosis with prior taxane or platinum-based chemotherapy. 2. CIPN symptoms staged as CTCAE Grade 1, 2, or 3. 3. Life expectancy \> 6 months and capable of independent ambulation. Exclusion Criteria: 1. Presence of a cardiac pacemaker. 2. Severe coagulation disorders. 3. Neuropathy from other etiologies (non-chemotherapy induced).
Where it's running
-
ShowChwanMH
Changhua, Changhua, Taiwan Recruiting -
Show Chwan Memorial Hospital
Changhua, Taiwan Recruiting
Study contacts
- Principal investigator: I-Ting Lee — Changhua Show Chwan Memorial Hospital
- Study coordinator: I-Ting Lee, Bachelor
- Email: iting.lee927@gmail.com
- Phone: +886-988567228
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Cryotherapy during weekly paclitaxel to reduce chemotherapy-induced numbness and tingling
This study tests whether applying cryotherapy to hands and feet during weekly paclitaxel helps prevent CIPN in women with breast cancer.
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Virtual exercise program to help with chemotherapy-induced nerve symptoms
This trial tests whether a remote, personalized exercise program (EX-CIPN) can reduce CIPN symptoms and related disability in cancer survivors who have persistent neuropathy after chemotherapy, compared with usual care.
-
Acupuncture and compression to prevent chemotherapy-induced nerve damage in breast cancer
This trial will test whether wearing compression garments and/or receiving acupuncture during taxane chemotherapy can prevent chemotherapy-induced peripheral neuropathy in adults with early-stage breast cancer.
-
PEA and Scutellaria combined with exercise for chemotherapy-related nerve pain
This trial will see if taking PEA and Scutellaria together with therapeutic exercise helps adults who have nerve pain after chemotherapy.
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Assessing Functional Impairments in CIPN Patients
This study tests how CIPN affects daily function by using functional tests alongside patient self-reports to see how well the tests reflect everyday difficulties.
-
Closed-loop spinal cord stimulation for painful chemotherapy-induced peripheral neuropathy
This observational project will try closed-loop spinal cord stimulation to reduce neuropathic pain in adults who developed peripheral neuropathy after chemotherapy.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.