Assessing Functional Impairments in CIPN Patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This cross-sectional study examines functional impairments in adults with chemotherapy-induced peripheral neuropathy (CIPN) and compares objective functional assessments with patient-reported outcomes. Participants complete questionnaires and undergo physical exams to measure daily activity limitations, gait and balance, and fine motor function. The goal is to better understand how objective tests correlate with patients’ subjective experiences and to identify which assessments best reflect real-world impact of CIPN.

Why it matters

Who can join: the full rules

Inclusion Criteria:

\- Male and female patients with CIPN grade ≥ 2, according to Common Terminology Criteria for Adverse Events for peripheral sensory or motor neuropathy (CTCAE) version 5

\- Age ≥ 18

\- Ongoing or completed neuropathy-inducing chemotherapy

\- Ability to stand and walk

\- Ability to fill out a questionnaire Inclusion criteria for healthy controls

\- Male and female adults (age ≥ 18)

\- Ability to stand and walk

\- Ability to fill out a questionnaire

Exclusion Criteria:

* Pre-existing clinically manifest peripheral neuropathy prior to start of chemotherapy (e.g. caused by radiation or malignant plexopathy, lumbar or cervical radiculopathy, carpal tunnel syndrome, B12 deficiency, AIDS, monoclonal gammopathy, diabetes, heavy metal poisoning amyloidosis, syphilis, hyperthyroidism or hypothyroidism, inherited neuropathy, etc.)

Acute or chronic injuries/ diseases of the musculoskeletal system affecting functional tests

\- Acute or chronic cardiovascular diseases affecting functional tests

\- Neurological disease affecting functional tests (for healthy controls)

\- Neurological disease other than CIPN affecting functional tests (for CIPN patients)

Where it's running

• Institute of Physical Medicine and Rehabilitation, University Hospital Salzburg
  Salzburg, Austria Recruiting

Study contacts

• Study coordinator: Florian Rieder, PhD
• Email: f.rieder@salk.at
• Phone: 00435725553182

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Cryotherapy during weekly paclitaxel to reduce chemotherapy-induced numbness and tingling

  This study tests whether applying cryotherapy to hands and feet during weekly paclitaxel helps prevent CIPN in women with breast cancer.

  Recruiting at 3 sites Azienda Sanitaria dell'Alto Adige · Bolzano, Bolzano and 3 other locations · NCT07780955

• Electroacupuncture and Exercise for Chemotherapy-Induced Peripheral Neuropathy

  This study tests whether adding a structured exercise program to electroacupuncture helps cancer survivors with CIPN more than electroacupuncture alone.

  Recruiting at 2 sites Show Chwan Memorial Hospital · Changhua, Changhua and 1 other locations · NCT07700901

• Virtual exercise program to help with chemotherapy-induced nerve symptoms

  This trial tests whether a remote, personalized exercise program (EX-CIPN) can reduce CIPN symptoms and related disability in cancer survivors who have persistent neuropathy after chemotherapy, compared with usual care.

  Recruiting Phase 3 University Health Network, Toronto · Toronto, Ontario · NCT07481149

• Acupuncture and compression to prevent chemotherapy-induced nerve damage in breast cancer

  This trial will test whether wearing compression garments and/or receiving acupuncture during taxane chemotherapy can prevent chemotherapy-induced peripheral neuropathy in adults with early-stage breast cancer.

  Recruiting Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University · Guangzhou, Guangdong · NCT07377279

• PEA and Scutellaria combined with exercise for chemotherapy-related nerve pain

  This trial will see if taking PEA and Scutellaria together with therapeutic exercise helps adults who have nerve pain after chemotherapy.

  Recruiting University of Palermo · Palermo, Italia · NCT07352514

• Closed-loop spinal cord stimulation for painful chemotherapy-induced peripheral neuropathy

  This observational project will try closed-loop spinal cord stimulation to reduce neuropathic pain in adults who developed peripheral neuropathy after chemotherapy.

  Recruiting at 5 sites Rijnstate Hospital · Arnhem and 4 other locations · NCT07304401

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.